摘要
目的:分析葡萄糖酸锌辅助治疗对轮状病毒性肠炎患儿心肌损伤、免疫功能及血清炎性因子的影响。方法:选择于本院接受住院治疗的轮状病毒性肠炎患儿138例作为研究对象,随机分为对照组(69例)接受临床常规治疗,观察组(69例)接受葡萄糖酸锌辅助治疗及对照组,比较两组的心肌酶谱、免疫功能及血清炎性因子的水平差异。结果:(1)观察组患儿接受葡萄糖酸锌辅助治疗后的乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(cTnⅠ)等心肌酶谱指标水平均明显低于对照组,差异具有统计学意义(P<0.05);(2)观察组接受葡萄糖酸锌辅助治疗后的血清CD19+CD5+CD1dh i B细胞表达水平高于对照组,CD11b及CD40-CD40L共刺激分子表达水平明显低于对照组,差异具有统计学意义(P<0.05)(3)观察组接受葡萄糖酸锌辅助治疗后的血清TRF1、TRF2表达水平高于对照组,IL-12表达水平均低于对照组,差异具有统计学意义(P<0.05)。结论:葡萄糖酸锌辅助治疗有助于避免轮状病毒性肠炎患儿的心脏损失,提升免疫功能、降低全身炎症水平。
Objective： To analyze the effects of Zinc gluconate adjuvant therapy on Rotavirus myocardial injury, im- mune function and serum inflammatory factors of children with viral enteritis. Methods： 138 Rotavirus viral enteritis children were enrolled as research objects. According to stochastic indicator method, they were divided into control group （n= 69 cases） which received clinical routine treatment, and observation group （n= 69 cases） which received Zinc gluconate adjuvant therapy, myocardial enzyme spectrum, serum inflammatory cytokines and immune function of the two groups were compared. Results： 1） LDH, CK, CK-MB, cTn 1 myocardial enzyme indexes of the observation group were significantly lower than that of the control group （P〈0.05）, 2） serum zinc gluconate auxiliary CD19＋ CD5＋ CDldh~ B cells expression level of the observation group were higher than that of the control group, CDllb and CD40-CD40L stimulus molecule expression levels of the observa- tion group were significantly lower than that of the control group （P〈0.05）. 3） Serum zinc gluconate auxiliary TRF1, TRF2 expression levels of the observation group were significantly higher than that of the control group but IL-12 level was lower than control group （P〈0.05）. Conclusion： Zinc gluconate adjuvant therapy could help to avoid the heart of the children with rotavirus virus enteritis loss, enhance immune function,reduce level of systemic inflammation.
出处
《海南医学院学报》
CAS
2015年第8期1100-1102,共3页
Journal of Hainan Medical University
基金
重庆市卫生局医学科研基金资助项目(2012-2-413)~~
