摘要
目的探讨肾动脉阻力指数(RRI)、肿瘤坏死因子α(TNF-α)和白细胞介素10(IL-10)在高血压肾损害患者中的变化及其相关性。方法将73例高血压病患者根据其尿蛋白排泄率分为2组:单纯高血压组(n=37)和高血压肾损害组(n=36),应用超声多普勒检测RRI,并采用放射免疫法检测血清TNF-α、IL-10浓度。同期选择30例健康体检者作为正常血压对照组。结果高血压病组RRI、TNF-α均高于正常血压对照组(P<0.05),其中高血压肾损害组RRI、TNF-α高于单纯高血压组(P<0.05)。高血压病组IL-10低于正常血压对照组(P<0.05),其中高血压肾损害组IL-10又低于单纯高血压组(P<0.05)。组间比较RRI、TNF-α和IL-10的差异有统计学意义(P<0.05)。高血压病组RRI、TNF-α、IL-10与尿蛋白排泄率相关(r=0.801,P<0.01;r=0.703,P<0.01;r=-0.613,P<0.01)。RRI和TNF-α呈正相关(r=0.609,P<0.001),与IL-10呈负相关(r=-0.533,P<0.01),而与血压水平无相关性。结论高血压肾损害患者RRI升高,RRI可作为高血压肾损害的评价指标。高血压肾损害患者TNF-α升高,IL-10水平降低,细胞因子系统的失衡可能参与了高血压肾损害的进展。
Objective To investigate the changes of renal resistive index（RRI） and the serum levels of necrosis alpha（TNF-α） and interleukin 10（IL-10） in patients with hypertensive renal damage,whereby to explore the correlation of RRI,TNF-α and IL-10 with the hypertensive renal damage.Methods Seventy three patients with primary hypertension were divided into two groups according to their urinary albumin excretion rate：simple hypertension group（n=37）,hypertensive renal damage group（n=36）.RRI was measured using Doppler ultrasonography,serum TNF-α and IL-10 using radioimmune assay.Thirty normotensive healthy persons were selected as normotensive control group.Results RRI and TNF-α in the hypertension group were higher than those in the normotensive control group（P0.05）,with RRI and TNF-α in the hypertensive renal damage group being higher than those in the simple hypertension group（P0.05） and IL-10 in the hypertension group was lower than that of normotensive control group（P0.05）,IL-10 in the hypertensive renal damage group was also lower than that of simple hypertension group（P0.05）.There was statistical significance in RRI,TNF-α and IL-10 between the groups（P0.05）.RRI,TNF-α and IL-10 in the hypertension group were associated with the urinary albumin excretion rate（r=0.801,P0.01;r=0.703,P0.01;r=-0.613,P0.01）.RRI was positively conelated with TNF-α（r=0.609,P0.001）,negatively correlated with IL-10（r=-0.533,P0.01）,but not correlated with the level of blood pressure.Conclusion RRI is remarkably increased in patients with hypertensive renal damage,whereby can be used as a parameter in evaluating hypertensive renal damage.TNF-α is increased and IL-10 decreased significantly in patients with hypertensive renal damage,indicating that the imbalanced cytokine network may play a role in the pathological mechanisms of hypertensive renal damage.
出处
《国际检验医学杂志》
CAS
2013年第13期1666-1668,1670,共4页
International Journal of Laboratory Medicine
基金
宁夏医科大学面上项目(No.200900)
