摘要
目的与阿昔洛韦相比较,观察伐昔洛韦治疗带状疱疹的有效性和安全性。方法采用随机、平行、对照的方法,将60例患者分成试验组和对照组,试验组30例,口服伐昔洛韦片1000 mg/次,3次/d,对照组30例,口服阿昔洛韦片800 mg/次,5次/d,两组同时服用7 d后,观察临床疗效,并随访6个月,记录患者带状疱疹后遗神经痛的情况。结果两组治疗带状疱疹的有效率分别为80%和76%,差异无统计学意义(P>0.05),但随访发现两组患者带状疱疹后遗神经痛的缓解率差异具有统计学意义(P<0.05)。结论伐昔洛韦与阿昔洛韦相比,两者治疗带状疱疹皮疹的有效率和不良反应的差异不显著,但是伐昔洛韦能够减轻患者的后遗神经痛,且具有较好的依从性。
Objective To compare the efficacy and safety of valaciclovir and acyclovir in treatment of herpes zoster.Methods A randomized,parallel controlled trials of anti-herpes agent was performed in 60 patients with herpes zoster.30 patients in the experimental group received 1000mg valaciclovir orally three times a day,while 30 patients in the control group received 800mg acyclovir orally five times a day.The courses were 7 days in both groups.The clinical efficacy was evaluated.The incidence of postherpetic neuralgia was recorded after the follow up of 6 months.Results The effective rate was 80% in the experimental group and 76% in the control group,the difference was not statistically significant（P〈0.05）;the difference in the remission rate of postherpetic neuralgia 6 months later was statistically significance（P〈0.05）.Conclusion The difference in effective rate and incidence of adverse reactions in the treatment of herpes zoster was not significant between valaciclovir and acyclovir.However valaciclovir can effectively reduce the postherpetic neuralgia and improve the treatment compliance of patients.
出处
《中华全科医学》
2013年第8期1183-1184,共2页
Chinese Journal of General Practice
