摘要
随着对PI3K信号通路研究的不断深入,近年来该通路在哺乳动物中的研究(特别是PI3K信号通路对哺乳动物生殖轴(HPG轴)即下丘脑–垂体–性腺轴的调控上)也取得了突破性的进展。目前,该信号通路对哺乳动物HPG轴的调控作用的研究已成为该研究领域的焦点,该文论述了PI3K信号通路中的几名成员对哺乳动物HPG轴的影响,如上游调控因子、雌激素及其受体等与下游靶蛋白、mTOR,从而有助于进一步解析哺乳动物卵巢功能的分子调控机制,并为其临床应用提供重要的参考资料。
With the deepening study of the phosphoinositide-3 kinase （PI3K） signaling pathway, there has been breakthrough progress in the mammalian during recent years, especially in the regulation of PI3K signaling on mammalian hypothalamic-pituitary-gonadal （HPG） axis, which has become focus in the present research areas. The present article discussed the effects of several members of PI3K signaling on mammalian HPG axis, which included the upstream regulatory factors： estradiol and ER etc. and the downstream target protein： mTOR, which would help further resolve the molecular mechanism of the mammalian ovary function and provide some important reference for clinical applications.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2013年第7期1068-1072,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:31101032
31271255)
教育部新世纪人才支持计划(批准号:NCET120614)
教育部博士点基金(批准号:20113503120002)
福建省高校杰青项目(批准号:AJ11041)资助的课题~~
关键词
PI3K
HPG轴
MTOR
phosphoinositide-3 kinase（PI3K）
hypothalamus-pituitary-gonadal（HPG） axis
mammalian target of rapamycin（mTOR）
