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肝细胞性肝癌合并门静脉癌栓63例临床治疗分析 被引量:6

Therapeutic effects analysis of sixty-three cases of hepatocellular carcinoma with portal vein tumor thrombus
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摘要 目的:比较不同治疗方法对肝细胞性肝癌(HCC)合并门静脉癌栓(PVTT)的疗效及其意义。方法:回顾性分析应用不同治疗方式治疗的63例原发性HCC合并门静脉主干或者第一分支癌栓患者的预后。按照治疗方式的不同分为4组:保守治疗组(A组,7例);TACE治疗组(B组,19例);手术切除原发HCC同时行门静脉切开取栓术或者癌栓部位门静脉切除术治疗组(C组,12例);手术切除原发HCC同时行门静脉切开取栓术或者癌栓部位门静脉切除术+术后TACE治疗组(D组,25例)。结果:A组中位生存期为2个月,半年、1年、2年、3年生存率分别为14%、0、0、0;B组中位生存期为6个月,半年、1年、2年、3年生存率分别为56%、12%、0、0;C组中位生存期为10个月,半年、1年、2年、3年生存率分别为、74%、37%、9%、0;D组中位生存期为16个月,半年、1年、2年、3年生存率分别为80%、52%、20、12%。各组生存率比较差异均具有统计学意义(P<0.05)。结论:原发性HCC合并PVTT采取手术切除原发肝癌同时行门静脉切开取栓术或者癌栓部位门静脉切除术可明显延长生存期,术后应用TACE治疗可进一步延长生存期,提高生存率。 Objective: To evaluate the efficacy of different treatment strategies for primaryhepatocellular carcinoma(HCC)with portal vein tumor thrombus(PVTT)through sixty-three cases of HCC with PVTT.Methods: Sixty-three HCC patients with PVTT in the first branch and/or main trunk of the portal vein were enrolled in this study.They were divided into four groups and underwent four different treatment.Group A,conservative treatment group,(n=7).Group B,TACE treatment group(n=19);Group C,surgical resection group(,n=12);Group D,surgical resection and TACE group(n=25).Results: The median survival time of the patients in Group A、B、C、D were 2 months 、6 months、10 months、16 months respectively;and the survival rates at 0.5-,1-,2-,and 3-year of the patients in Group C、D were 74%、37%、9%、0 respectively;and the survival rates at 0.5-,1-,2-,and 3-year of the patients in Group D were 80%、52%、20、12% respectively.Conclusion: Resection of HCC and removal of PVTT may prolong the survival period of patients with HCC and PVTT.Treatment of postoperative TACE may improve their survival.
出处 《中国现代普通外科进展》 CAS 2013年第6期447-450,共4页 Chinese Journal of Current Advances in General Surgery
关键词 肝细胞性肝癌 门静脉癌栓 治疗 中位生存期 生存率 Hepatocellular carcinoma·Portal venous tumor thrombus·Treatment·Median survival time·Survival rates
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  • 1Masami Minagawa,Masatoshi Makuuchi.Treatment of hepatocellular carcinoma accompanied by portal vein tumor thrombus[J].World Journal of Gastroenterology,2006,12(47):7561-7567. 被引量:78
  • 2Niu Z J, Ma YL, Kang P, et al. Transarterial chemoembolization compared with conservative treatment for advanced hepatoce!lular carcinoma with portal vein tumor thrombus: using a new classifica- tion[ J]. Med Onco1,2012,29 (4) :2992-2997.
  • 3Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma [ J ]. N Engl J Med, 2008,359 ( 4 ) : 378-390.
  • 4Cheng AL, Kang Y K, Chen Z, et al. Efficacy and safety of sor- afenib in patients in the Asia-Pacific region with advanced hepa- tocellular carcinoma: a phase III randomized, double-blind, place- bo-controlled triM[ J]. Lancet Onco1,2009,10( 1 ) :25-34.
  • 5Irtan S, Laly XC, Ronot M, et aI. Complete regression of locally advanced hepatoceUular carcinoma induced by sorafenib allowing curative resection[ J]. Liver Int,2011,31 (5) :740-743.
  • 6Curtit E, Vuillemin AT, Nguyen T, et al. Complete histologic re- sponse induced by sorafenib in advanced hepatocellular carcino- ma: a ease report [ J]. J Clin Oncol,2011,29 ( 12 ) :330-332.
  • 7Premal D,Jonathan E,Garrt R,et al. Sustained Complete Remis- sion of Metastatic Hepatocellular Carcinoma with Single Agent Sorafenib[ J]. J Gastrointest Cane,2013,44( 1 ) :98-101.
  • 8Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular eareinomas in patients with cirrhosis[J]. N Engl J Med,1996,334( 11 ) :693-699.
  • 9Yeo W, Mok TS, Zee B, et al. A randomized phase Ⅲ study of doxorubicin versus eisplatin/interferon alpha-2b/doxorubicin/flu- omuracil(PIAF) combination chemotherapy for unreseetable hep- atocellular carcinoma [ J ]. J Natl Cancer Inst, 2005,97 ( 20 ) : 1532-1538.
  • 10Tang Qing-he, Li Ai-jun, Yang Guang-ming, et al. Surgical Resec- tion Versus Conformal Radiotherapy Combined With TACE for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus[ J]. World J Sur,2013,37 : 1362-1370.

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