摘要
目的优选五倍子软膏剂的最佳处方。方法以软膏的外观性状、稳定性为考察指标,采用正交设计法进行实验,以蜂蜡用量、乳化剂用量、主要的加入方式为可变因素,并测定流变学参数。结果优化处方A2B3C2,即蜂蜡2%,span-80 4%,加药方式为药物加入油相。结论该软膏处方设计合理,制剂稳定性较好。
Objective To optimize the best prescription of gallnut extract ointment. Methods With appearance and stability of ointment as index, orthogonal design experiment was carried out, with beeswax amount, the amount of emulsifier and the major adding method as the variables,the rheological parameters were determined. Results Optimized prescription was A2B3C2 ,which including 2% beeswax,4% span-80,and the way was to put the drug into oil phase. Conclusion The ointment formulation is reasonable, and the preparation has good stability.
出处
《实用药物与临床》
CAS
2013年第4期318-320,共3页
Practical Pharmacy and Clinical Remedies
关键词
正交设计
五倍子软膏
处方
Orthogonal design
Gallnut extract ointment
Prescription
