摘要
目的:优化黄连软膏的制备工艺。方法:以浸膏得率、总生物碱含量、综合评分为评价指标,选取乙醇体积分数、乙醇用量、提取时间和提取次数为考察因素,采用正交试验优选提取工艺;通过稳定性考察,比较5个不同软膏基质处方对黄连软膏成型性与质量的影响。结果:黄连、黄柏最佳提取工艺为6倍量70%乙醇提取2次,每次1.5 h;软膏基质组成为十八烷醇、液体石蜡、白凡士林、单硬脂酸甘油酯、吐温-80、司盘-60、甘油、双蒸水。结论:优选的黄连、黄柏生物碱提取工艺和软膏成型工艺稳定可行,可推广应用于大生产。
Objective： To optimize preparation process of Huanglian ointment. Method： With yield of extract, the content of total alkaloid and composite score as indexes, extraction technology was optimized by orthogonal test with the concentration of ethanol, solid-liquid ratio, extraction time and extraction times as factors; Effect of five different ointment matrix prescriptions on formation and quality of Huanglian ointment was compared by stability experiment. Result： Optimum extraction process was： extracted 2 times with 6 times the amount of 70% ethanol, 1.5 h per time; Ointment matrix composition as follows： octadecanol, liquid paraffin, white petrolatum, glycerin monostearate, Tween-80, Span-60, glycerin, double distilled water. Conclusion： This optimized extraction technology and ointment molding process was stable and feasible, it could be applied to largescale production.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第17期36-38,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
江西省自然基金项目(2007GQY2288)
江西中医学院校级课题(jzjg2011-15)
关键词
正交设计
提取工艺
软膏剂
处方
orthogonal design
extraction process
ointment
prescription
