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胸椎和腰椎脊柱结核手术入路术式选择研究 被引量:26

Selection of Surgical Approaches for Thoracic and Lumbar Spinal Tuberculosis
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摘要 目的分析胸椎和腰椎结核及3种手术入路,确定脊柱结核手术的入路选择。方法收集54例短程化疗联合病灶清除植骨融合术的脊柱结核患者手术时间,术中出血,后凸畸形的矫正角度和椎体高度的重建等数据作为评估指标。组间均数的差别采用单向方差分析。结果前后联合入路组手术时间大于前路组(P<0.05)。前路组椎高重建大于后路组或前后联合入路组(P<0.05)。胸椎结核联合入路组的术中出血大于前路组或后路组(P<0.05),腰椎结核无此差异(P>0.05)。结论前路手术适合椎体破坏严重伴塌陷,有待重建椎体高度的脊柱结核,前后联合入路因其较长的手术时间不适合基础情况较差的患者,但较长的手术时间并没有明显增加腰椎结核的术中出血。 Objective To analyze the three different operative approaches for thoracic and lumbar spinal tuberculosis, so as to determine the optimal operative approach to treat spinal tuberculosis. Methods Fifty-five patients with spinal tuberculosis who received anti-tuberculo- sis drug and surgical therapy were recruited. The clinical data of patients were collected including surgical time, blood loss,kyphosis correc- tion and vertebra height reconstruction. Differences of means within groups were statistically evaluated by one-way analysis of variance. Re- sults The surgery time in combined anterior and posterior approach (CAPA) group was longer than that in anterior approach (AA) group (P 〈 0.05 ) ; the average vertebral body height reconstruction in AA group was larger than that in posterior approach (PA) or CAPA group (P 〈 0.05 ), no such difference was found in lumbar spinal tuberculosis. Conclusion AA is suitable for the serious vertebral collapse that needs reconstruction of the height of vertebrae. CAPA was not suitable for the patients with poor basic condition because of the prolonged op- eration time, but the extended operation time were not associated with obviously increased blood loss in lumbar spinal tuberculosis.
出处 《中国医科大学学报》 CAS CSCD 北大核心 2013年第3期253-256,共4页 Journal of China Medical University
基金 广东省自然科学基金(S2012010009374)
关键词 脊柱结核 手术入路 后凸畸形 椎高重建 spinal tuberculosis operative approach kyphosis vertebra height reconstruction
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参考文献12

  • 1Dunn R. The medical management of spinal tuberculosis [ J ]. SA Orthopaedic J,2010,9( 1 ) :37-41.
  • 2刘鹏,江建明.高效液相色谱法测定脊柱结核化疗后组织内利福平和去乙酰利福平的浓度[J].中国医科大学学报,2011,40(7):665-668. 被引量:7
  • 3刘鹏,江建明,周枝凤.HPLC法检测脊柱结核病椎内外异烟肼和乙酰异烟肼浓度[J].南方医科大学学报,2010,30(2):364-367. 被引量:8
  • 4Pointillart V,Aurouer N,Gangnet N,et al. Anterior approach to the cervicothoracic junction without sternotomy : a report of 37 cases [ J ]. Spine (Phila Pa 1976), 2007,32(25 ) : 2875-2879.
  • 5Jin D, Qu D, Chen J, et al. One-stage anterior interbody autografting and instrumentation in primary surgical management of thoracolum- bar spinal tuberculosis [ J ]. Eur Spine J, 2004, 13 ( 2 ) : 114-121.
  • 6Kim DJ,Yun YH,Moon SH,et al. Posterior instrumentation using compressive laminar hooks and anterior interbody arthrodesis for the treatment of tuberculosis of the lower lumbar spine [ J ]. Spine, 2004, 29(13) : E275-E279.
  • 7Guven O, Kumano K, Yalcin S, et al. A single stage posterior ap- proach and rigid fixation for preventing kyphosis in the treatment of spinal tuberculosis[J]. Spine, 1994, 19(9) : 1039-1043.
  • 8Hirakawa A,Miyamoto K,Ohno Y,et al. Two-stage (posterior and anterior) surgical treatment of spinal osteomyelitis due to atypical mycobacteria and associated thoracolumbar kyphoscoliosis in a non- immunocompromised patient [ J ]. Spine, 2008,33 ( 7 ) : E221-E224.
  • 9Erturer E,Tezer M,Aydogan M,et al. The results of simultaneous posterior-anterior-posterior surgery in multilevel tuberculosis spondylitis associated with severe kyphosis[ J ]. Eur Spine J, 2010,19 (12) :2209-2215.
  • 10Parthasarathy R,Sriram K,Santha T, et al. Short-course chemother- apy for tuberculosis of the spine. A comparison between ambulant treatment and radical surgery--ten-year report[J ]. J Bone Joint Surg Br, 1999,81 ( 3 ) : 464-471.

二级参考文献26

  • 1戈朝晖,王自立,魏敏吉.利福平在脊柱结核患者不同组织分布的实验研究[J].中国脊柱脊髓杂志,2004,14(12):741-744. 被引量:21
  • 2Lennard L. Therapeutic drug monitoring of antimetabolic cytotoxic drugs[J]. Br J Clin Pharmacol, 1999, 47(2): 131-43.
  • 3Dahl ML, Sjoqvist F. Pharmacogenetic methods as a complement to therapeutic monitoring of antidepressants and neuroleptics [J ]. Ther Drug Monit, 2000, 22(1): 114-7.
  • 4Tuli SM, Kumar K, Sen PC, et al. Penetration of antitubercular drugs in clinical osteoarticular tubercular lesions [J]. Acta Orthop Scand, 1977, 48(4): 362-8.
  • 5Kumar K. The penetration of drugs into the lesions of spinal tuberculosis[J]. Int Orthop, 1992, 16(1): 67-8.
  • 6World Health Organization. Stop TB Dept. Guidelines for the programmatic management of drug-resistant tubereulosised [C]. Geneva: World Health Organization, 2008.
  • 7Fox HH, Gibas JT. Synthetic tuberculostats. VIH. Acyl derivatives of isonicotinyl hydrazine[J]. J Org Chem, 1953, 34(6): 1375-9.
  • 8van Assendelft OW, Zijlstra WG, Buursma A, et al. The use of atomic absorption spectrophotometry for the measurement of haemoglobin-iron, with special reference to the determination of epsilon(540)(HiCN) [ J ]. Clin Chim Acta, 1968, 22(2): 281-9.
  • 9Roncoroni A J, Manuel C, Nedjar C, et al. Cefamandole bone diffusion in patients undergoing total hip replacement [J]. Chemotherapy, 1981, 27(3): 166-72.
  • 10Chen B, Cai W, Li J, et al. Estimating N-acetyltransferase metabolic activity and pharmacokinetic parameters of isoniazid from genotypes in Chinese subjects [J]. Clin Chim Acta, 2009, 405(1): 23-9.

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