摘要
结核病是世界范围内最常见的传染性疾病之一,近年来,结核病的发病率逐年提高,其中结核杆菌对传统抗结核药物产生耐药性是结核这种古老并严重危害人群健康的疾病发病率抬头的重要原因。在抗结核新药的研发没有取得重大突破的前提下,患者的治疗仍然依靠传统的抗结核药物,这种抗结核治疗的现状要求我们必须对传统药物制定更为合理化、规范化、精准化的给药方案。采用科学的临床分析检测方法提供合理的给药方案,优化抗结核方案,减少结核药毒副作用,从而降低治疗不当引发耐药结核;在目前的抗结核药物治疗中意义重大。因此,本文主要对近年来国内外在结核治疗中,临床应用异烟肼、利福平、吡嗪酰胺、乙胺丁醇所用的分析检测方法进行综述,为抗结核药物临床的合理应用提供理论依据。
Tuberculosis（TB） is one of the most common infectious diseases in the world.In recent years,the incidence of TB increased year by year.The drug resistance of TB bacili toward traditional anti-TB drugs is the major reason of disease incidence rate rising and causes serious damage to people health.The treatment of patients still relies on traditional anti-TB drugs when there are no major breakthroughs of anti-TB drug research and development.Current situation requires us to make more rationalization,standardization and precise dosage plan when using traditional anti-TB medicine.It is essential to apply scientific clinical analysis method to provide reasonable dosage,to optimiz TB scheme and reduce side effects.Thus malpractice causing drug-resistant of TB in the present anti-TB drug treatment can be reduced.Therefore,in this paper,analysis of the detection method for isoniazid,rifampin,pyrazinamide,ethambutol in TB treatment were reviewed.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2018年第2期207-213,共7页
Chinese Journal of Pharmaceutical Analysis
基金
青海省青藏高原植物化学重点实验室-创新平台建设专项(2017-ZJ-Y19)
关键词
结核病
抗结核药
异烟肼
利福平
吡嗪酰胺
乙胺丁醇
临床检测
分析技术方法
tuberculosis
anti-tuberculosis drug
isoniazid
rifampin
pyrazinamide
ethambutol
clinical testing
analysis technique method
