摘要
作为非病毒基因载体,磁性纳米基因载体主要指无机非金属材料纳米氧化铁和铁氧体等,近年来其研究广受关注。文中对非病毒基因载体磁性纳米颗粒的种类、性质、制备方法和表面修饰进行综述,并介绍了磁性纳米基因载体介导的体内外基因转染,以及联合磁热疗与靶向治疗癌症领域的相关进展。
Magnetic nano-gene mainly refers to inorganic non-metallic materials including nano ferric oxide and ferrite, etc. Recently, research causes wild public concern on magnetic nanoparticles as non-virus gene vector. The paper demonstrates the types and properties, the common preparation methods and surface modification of magnetic nanopartieles as non-virus gene carrier. And the latest application of gene transfection of magnetic nanoparticles in vitro and in vivo, combined with magnetic fluid hyperthermia（MFH） or target therapy to cancer are reviewed.
出处
《医学研究生学报》
CAS
北大核心
2013年第2期186-189,共4页
Journal of Medical Postgraduates
基金
国家863计划(2007AA03Z356)
国家自然科学基金(30770584
81171452)
江苏省自然科学基金(BK2010357)
