摘要
氧化铁磁性纳米粒子通过表面化学修饰得到无机、有机或聚合物壳包覆在其表面。其中的壳结构既具有生物适应性,又具有可键合生物分子如细胞、蛋白质、酶、抗体和核酸的活性基团,而核具有磁性特性。本文总结了氧化铁磁性纳米粒子的制备方法,介绍了其表面化学修饰及在分离和分析应用的最新进展。
Iron oxide magnetic nanoparticles with biocompatibility and functional coatings via appropriate surface chemistry approaches have been used for immobilization of cells, proteins, enzymes, antibodies, oligonucleotides and drugs through covalent bonding or adsorption. The surface-modified magnetic nanoparticles have been widely used in biological and biomedical areas such as immobilization of biomolecules; separation of metal ions, cells, proteins, DNA; immunoassay, biochemical analysis and magnetic resonance imaging （MRI） probes. In this paper, preparation methods, surface modification approaches and analytical applications of iron oxide-based magnetic nanoparticles are reviewed.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2006年第10期1288-1297,共10页
Progress in Chemistry
基金
国家自然科学基金项目资助(No.20375019)
关键词
氧化铁
磁性纳米粒子
制备
表面修饰
磁性分离
生化检测
iron oxide
magnetic nanoparticles
synthesis
surface modification
magnetic separation
biochemical analysis
