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肿瘤细胞免疫原性死亡相关分子的研究进展 被引量：5

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摘要 用多种化学药物和放射线治疗肿瘤时,肿瘤细胞可发生免疫原性细胞死亡,即肿瘤细胞在发生凋亡的同时,由非免疫原性的细胞转变为具有免疫原性的细胞,并在机体内激发抗肿瘤免疫效应。肿瘤细胞的免疫原性死亡是一种有多种信号分子和细胞因子参与的复杂过程,这些分子的细胞定位和表达水平的改变直接影响死亡肿瘤细胞与免疫细胞之间的相互作用。对肿瘤细胞免疫原性死亡机制的深入研究可为肿瘤的免疫治疗提供新的依据和手段。本文简要综述了与肿瘤细胞免疫原性死亡相关分子的研究进展。
作者 王清 王艳林
机构地区 三峡大学医学院
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2013年第1期109-111,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(30973445)
关键词 免疫原性细胞死亡 树突状细胞 钙网蛋白 热休克蛋白 高迁移率族蛋白B 三磷酸腺苷
分类号 R392.12 [医药卫生—免疫学]
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参考文献29

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二级参考文献13

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细胞与分子免疫学杂志
2013年 第1期

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