摘要
目的 研究肺癌组织中肿瘤浸润树突状细胞 (TIDC)的浸润程度对预后的影响。方法将S 10 0蛋白作为TIDC的特异性标记物 ,应用SABC免疫学方法检测肺癌组织中TIDC的分布。结果38例肺腺癌中 ,TIDC显著浸润 15例 ,5年生存率为 6 0 0 % ;轻度浸润 2 3例 ,5年生存率 2 1.7%。 44例鳞癌中 ,TIDC显著浸润 18例 ,5年生存率 6 1.1% ;轻度浸润 2 6例 ,5年生存率 19.2 %。经Log rank检验 ,无论肺腺癌和鳞癌 ,TIDC显著浸润组和轻度浸润组的 5年生存率之间差异有显著性。结论 肺癌组织中TIDC显著浸润者的预后明显好于轻度浸润者。
Objective To study the degree of infiltration of dendritic cells in lung cancer in relation to prognosis.Methods S 100 protein as the marker of tumor infiltraing dendritic cells (TIDC) was stained immunohistochemically in lung cancer specimens. The degree of infiltration was considered mild and marked according to the criteria reported by Furukawa. The survival rate was obtained by Log rank test of the data.Results In 15 of 38 adenocarcinomas, whose TIDC infiltration was marked, the five year survival rate was 60.0%, while in 23 with mild TIDC infiltration, the five year survival rate was 21.7% ( P <0.01) Quite similar data were obtained from 44 squamous cell carcinomas. Significantly higer five year survival rate (61.1%) was observed in those with marked TIDC than those with mild infiltration (19.2%).Conclusion The degree of TIDC infiltration is positively correlated with the survival rate of lung carcinoma patients. Subject
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2000年第2期135-137,共3页
Chinese Journal of Oncology
关键词
肺肿瘤
肿瘤浸润
树突细胞
预后
Lung neoplasms
Tumor infiltrating dendritric cells
Prognosis
