摘要
目的 研究凋亡相关基因bcl-2在食管鳞癌及癌旁组织中的表达及意义。方法 应用Envision二步法检测62例食管鳞癌及癌旁组织中bcl-2蛋白的表达。结果 bcl-2在单纯增生、高级别上皮内瘤变及鳞癌组织中表达率分别为80.3 %,45.9%及67.7%，而正常食管黏膜组织中未见表达。正常粘膜组与其余各组之间有显著性差异（P﹤0.05）；bcl-2蛋白表达与食管鳞癌的病理分级、浸润深度无相关性（ P﹥0.05），但bcl-2蛋白的表达与淋巴结转移有相关性（P﹤0.05）。结论 bcl-2可能在食管癌早期阶段发挥作用，可能成为判断食管鳞癌预后的指标之一。
Objective To study the expression and significance of bcl-2 protein in esophageal squamous cell cancer and the surrounding tissues. Methods Envision method was used to analyze the expression of bcl-2 protein in 62 esophageal squamous cell cancer and the surrounding tissues. Results Expressions of bcl-2 protein were 80.3%,45.9%,45.9% and 67.7% in simple hyperplasia, high grade intraepithelial neoplasia and squamous cell carcinoma tissues respectively, but none in normal mucosa tissue. There were significant differences between normal esophageal mucosa and other groups （ P﹤0. 01） ; The expression of bcl-2 had no differentiation in grade of carcinoma、invasion（ P﹥0. 05） .But it had significant relationship in the expression of bcl-2 and lymph node metastasis（P﹤0.05）. Conclusion bcl-2 plays the roles in the different stage of occurrence of esophageal squamous cell cancer, bcl-2 may predicting the occurrence of esophageal squamous cell cancer in early stage, and may be regarded as an useful index for prognosis.
出处
《肿瘤研究与临床》
CAS
2012年第9期622-624,共3页
Cancer Research and Clinic
基金
山西省留学人员科研项目（105）
