摘要
目的探讨人微小病毒B19（HPVB19）与自然流产的相关性。方法选取30例自然流产患者作为病例组。随机抽取30例同期正常妊娠的孕妇作为对照组。所有受试者均记录自然流产的潜在危险因素。抽取所有受试者肘静脉血，采用巢式聚合酶链反应法检测HPVB19DNA，采用ELISA法检测HPVB19IgM抗体。采用Logistic多元回归分析法进行多因素分析。结果两组孕次≥2次，合并高血压、糖尿病，HPVB19DNA阳性率比较差异有统计学意义[43．3％（13，30）比13．3％（4／30）、33-3％（10／30）比6．7％（2／30）、30．0％（9／30）比6．7％（2，30）、36．7％（11／30）比3．3％（1／30）]（P〈0．05）；而HPVB19IgM抗体阳性率比较差异无统计学意义（P〉0．05）。多因素分析显示，孕次≥2次、合并高血压、HPVB19DNA阳性是孕妇发生自然流产的独立危险因素（OR=1．85、1．95、4．85，P〈0．05）。HPVB19DNA阳性患者早期自然流产发生的风险明显高于晚期自然流产，差异有统计学意义（P〈0．05）。结论HPVB19感染是自然流产患者的独立危险因素，需要早期检测并对妊娠孕妇进行必要的干预，以降低自然流产的发生。
Objective To investigate the correlation between human parvovirus （HPV） B19 and spontaneous abortion. Methods Participants included 30 cases of spontaneous abortion patients （patients group） and 30 normal pregnancy （control group）. The potential risk of spontaneous abortion factors were recorded. Extracting all subjects cubits venous blood, HPV B 19 DNA was tested by nested polymerase chain reaction, and HPV B 19 IgM antibodies were determined by ELISA. The more factors analysis were performed by Logistic multiple regression analysis. Results There were significant differences in gravidity more than 2 times, combined with hypertension, combined with diabetes, HPV B19 DNA positive expression between patients group and control group [43.3%（13/30） vs. 13.3%（4/30）, 33.3%（10/30） vs. 6.7%（2/30） ,30.0% （9/30） vs. 6.7% （2/30）, 36.7% （11/30） vs. 3.3% （1/30） ] （P 〈 0.05）. Logistic multiple regression analysis showed that gravidity more than 2 times, combined with hypertension, HPV B19 DNA positive expression were the independent risk factors of spontaneous abortion （OR = 1.85,1.95,4.85,P 〈 0.05）. There was significant difference in the risk between early spontaneous abortion and lately spontaneous abortion in HPV B 19 DNA positive expression patients （P 〈 0.05 ）. Conclusions HPV B 19 infection is the natural abortion independent risk factors, need to early detection of pregnancy, and carry out necessary intervention in pregnant women, in order to reduce the occurrence of natural abortion.
出处
《中国医师进修杂志》
2012年第27期28-31,共4页
Chinese Journal of Postgraduates of Medicine
关键词
流产
自然
人微小病毒B19
Abortion, spontaneous
Human parvovirus B19
