摘要
目的研究老年原发性高血压(Essential hypertension,EH)患者脉压(Pulse pressure,PP)与血栓前状态分子标志物的相关性,探讨其易并发血栓性疾病的机制,为临床早期诊治提供客观依据。方法测量148例老年EH患者的PP,根据PP分为PP1组(PP≤60 mmHg)、PP2组(60 mm<PP≤80 mm Hg)和PP3组(PP>80 mmHg);检测患者血浆血栓前状态(Prethrombotic state,PTS)分子标志物血管性血友病因子(Von Willebrand factor,vW F)、D二聚体(D-dimer)、纤维蛋白原(Fi-brinogen,FIB)的含量。结果 PP与PTS分子标志物水平有较好的相关性;随着PP的升高,PTS分子标志物水平也随之增加,差异有统计学意义(P<0.05)。结论老年EH患者的PP与血浆PTS分子标志物明显相关。PTS与病情进展及血栓性疾病的发生密切相关。
Objective To study the relationship between pulse pressure（PP） and molecular markers of prethrombotic state in old patients with essential hypertension. Methods The PP was measured in 148 cases of elderly patients with essential hypertension. The old patients were divided into three groups：PP1 group （PP≤60 mmHg） ;PP2 group （60 mm〈 PP≤ 80 mmHg） ;PP3 group （PP 〉 80 mmHg）. Molecular markers of prethrombotic state （ vWF, D-direct and FIB） were analyzed. Results As the pressure increases, PTS molecular markers levels also increases, the difference was statistically significant （P 〈 0.05 ）. Pulse pressure and PTS molecular marker levels have good relativity. Conclusions In elderly patients with essential hypertension pulse pressure and plasma PTS molecu- lar markers have obvious correlatio. PTS maybe closely related to the progress of the disease and the occurrence of thrombotic diseases.
出处
《实用医院临床杂志》
2012年第5期62-64,共3页
Practical Journal of Clinical Medicine
关键词
高血压
脉压
血栓前状态
老年
Hypertension
Pulse pressure
Prethrombotic state
Eldorly
