摘要
目的探讨高胆红素血症神经毒性对新生儿神经行为的影响。方法回顾性分析我院2008年1月。2011年10月收治入院的足月新生儿高胆红素血症患儿160例（观察组）临床资料，另选择我院同期正常足月生理性黄疸新生儿160例作为对照组，两组均采用总胆红素与白蛋白比值（B／A）与脑干听觉诱发电位（ABR）进行检测．并测查新生儿神经行为（NBNA）进行比对。结果观察组TBC、B／A比值测定结果与对照组比较差异有统计学意义（均P〈0．05）。ABR111波、V波潜伏期及I-Ⅲ、I-V波间期与对照组相比，差异均有统计学意义（均P〈0．05）。①高胆患儿NBNA评分均低于对照组，两者差异均有统计学意义。观察组NBNA评分均低于对照组，两者差异均有统计学意义（均P〈0．05）@B／A与NBNA评分的直线相关分析显示两者之间具有负相关关系（r=-0．46，P〈0．05）。结论①NBNA评分可应用早期诊断高胆所致的脑损伤。②B／A可作为评估胆红素神经毒性危险因素的指标之一。@ABR对了解新生儿早期听神经及脑干功能障碍有重要价值。
Objective To explore the influence of neurotoxic effect of hyperbilirubinemia to neurobehavioral function of newborn. Methods The clinical data of 160 full term infants with hyperbilirubinemia were retrospectiveanalyzed in hospital from January 2008 to Octorber 2011 as observation group, while 160 normal term newborn with physiological jaundice were collected as control group. The total bilirubin （TBC）, B/A and ABR were measured in both groups, and NBNA was per- formed and compared. Results Compared with that of control group, TBC and B/A in observation group had significant dif- ference （P 〈 0.05）.Ⅲ wave, latency period of V wave and I-Ⅲ, I -V wave interval of ABR also had the statistical significance. NBNA scores of hyperbilirubinemia of newborn in observation group were remarkably lower than that in con- trol. Linear correlation analysis showed that B/A and NBNA score was negative correlation （r = -0.46, P 〈 0.05）. Conclu- sion NBNA score can be applied to the early diagnosis of brain damage caused by hyperbilirubinemia. B/A can be used as an index of evaluating neurotoxicity risk factors of bilimbin. ABR has important value in understanding early auditory and brainstem dysfunction of newborn.
出处
《中国医药导报》
CAS
2012年第15期56-58,共3页
China Medical Herald
