摘要
目的:探讨小b值扩散加权成像(DWI)在诊断乳腺癌中的价值。方法:采用Philips 1.5T磁共振扫描仪对48例乳腺疾病患者行常规SE序列扫描、单次激发自旋回波-回波平面成像(SE-EPI)序列DWI及动态增强扫描。48例患者共检出53个病灶,其中良性肿瘤29个,恶性肿瘤24个,均经手术及病理证实;选择健康志愿者20例作为对照组。分析病灶与正常腺体组织的DWI信号特点,定量比较分析病变组与对照组之间及良恶性组之间表观扩散系数(ADC)值的差异。结果:除2例原位癌及1例小纤维瘤未显示外,其他良恶性病变DWI均可显示。恶性组平均ADC值[(1.41±0.37)×10-3 mm2/s]明显低于对照组[(2.01±0.36)×10-3 mm2/s]和良性组[(1.98±0.42)×10-3 mm2/s],差异均有统计学意义(P<0.05)。良性组ADC值与对照组比较,差异无统计学意义(P>0.05)。以ADC值作为诊断指标进行ROC分析,诊断阈值为1.542×10-3 mm2/s,诊断敏感度为86.4%,特异度为89.3%。结论:ADC值是鉴别乳腺癌有价值的参数,小b值扩散加权成像对于乳腺癌的鉴别诊断具有重要价值。
Objective：To evaluate the role of low b value diffusion-weighted imaging（DWI） in detecting breast tumors.Methods：Forty-eight female patients underwent breast MRI with Philips Gyroscan-NT 1.5PT including SE-echo planar（SE-EPI）,DWI and dynamic contrast-enhanced MRI.Fifty-three breast lesions were detected on DWI and the histological diagnoses were as follows：24 malignant lesions and 29 benign lesions.Twenty healthy volunteers served as the control group.Analysis of the DWI signal characteristics of the lesions and normal breast tissues and quantitative analysis and comparison of the apparent diffusion coefficient（ADC） value differences between patients and controls,benign group and malignant group were made.Results：Except for 2 cases of carcinoma in situ and 1 case with small fibroma not being shown,other benign and malignant lesions of DWI were all demonstrated.The mean ADCs of the malignant lesions were significantly lower than those of the benign lesions（P0.01） and the normal tissues（P0.01）.There was no difference between the benign lesions and normal tissues.The mean ADC value of breast tumors was 1.542×10-3mm2/s according to receiver operator characteristic curve（ROC） criteria.The sensitivity and specificity of the ADC value for breast tumors were 86.4% and 89.3%.Conclusion：The ADC value is useful in differentiating malignant breast lesion from benign and normal breast tissue.Low b value DWI is an effective imaging technique for detecting breast lesions.
出处
《放射学实践》
2012年第5期512-515,共4页
Radiologic Practice
基金
乌鲁木齐市科技计划项目(Y08131008)
关键词
乳腺肿瘤
磁共振成像
诊断
鉴别
Breast neoplasm
Magnetic resonance imaging
Diagnosis
differential
