摘要
目的探讨局部和全身应用甲氨蝶呤保守治疗瘢痕妊娠的临床效果及安全性。方法选择2008年8月至2011年2月间,我院收治的确诊剖宫产术后子宫瘢痕处妊娠患者30例,随机分为A、B两组,每组各15例。A组孕囊内局部注射甲氨蝶呤50mg,隔日1次,共3次;B组肌注甲氨蝶呤20mg/次,连续5d,同时口服米非司酮25mg,12h1次。比较两组的治疗效果及不良反应发生情况。结果 A组治愈13例(86.7%),出现转氨酶升高2例,胃肠道反应4例,口腔溃疡1例;B组治愈14例(93.3%),出现转氨酶升高2例,胃肠道反应5例,口腔溃疡2例,脱发1例。A、B两组的治愈率、副反应发生情况的差异并无统计学意义(P>0.05)。结论甲氨蝶呤联合米非司酮治疗瘢痕妊娠效果良好,治愈率高,安全性较好;全身用药与局部用药临床效果及安全性并无显著不同。
Objective To investigate the effect and security in abortioning cesarean scar pregnancy（CSP）using methotrexate partly or whole body.Method 30 cases diagnosed as CSP,were divided into two groups（A and B,15cases per groups）,from August 2008 to February,2011.The A group was treated by methotrexate（50mg） injecting into gestational sac directly,every other day,3 times in all;The B group was treated by methotrexate（25mg）intramu scular,for 5 days,and mifepristone oral,once every 12 hours.Then compared the effec and adverse reactions of the two groups.Results There were 13 cases（86.7%）cured,2 cases elevated transaminase,4 cases gastrointestinal reaction and 1 case oral ulcers in A group.While there were 14 cases（93.3%）cured,2 cases elevated transaminase,5 cases gastrointestinal reaction,2 cases oral ulcers and 1 case hair loss in B group.But there was no significant difference between the two groups.Conclusion Patients with CSP shoul get benefits by treating with methotrexate combined with mifepristone,wich has higher cure rate and are more security.There is no difference in effect and security when using methotrexate partly or whole body.
出处
《中国医药指南》
2012年第11期76-77,共2页
Guide of China Medicine
关键词
甲氨蝶呤
米非司酮
瘢痕妊娠
局部
全身
Methotrexate
Mifepristone
Cesarean scar pregnancy
Partly
Whole bdoy
