摘要
目的观察阿托伐他汀对慢性充血性心力衰竭患者心功能、脑钠尿肽（BNP）及C反应蛋白（CRP）的影响。方法将78例慢性充血性心力衰竭患者按随机数字表法分为对照组和阿托伐他汀组，每组39例。两组均采用利尿剂、强心剂、β受体阻滞剂等常规治疗，阿托伐他汀组在常规治疗的基础上加用阿托伐他汀钙20mg，1次/d。两组疗程均为6个月。治疗前后行心脏超声心动图检查并检测血浆CRP、BNP水平。结果两组治疗后左室射血分数（LVEF）明显升高，左室舒张末期内径（LVEDd）、左室收缩末期内径（LVEsd）明显降低，与治疗前比较差异均有统计学意义（P〈0．05）；阿托伐他汀组治疗后LVEF明显高于同期对照组[（46．75±5．82）％比（40．58±4．92）％]（t=4．016，P〈0．05），LVEDd、LVESd明显低于同期对照组[（49．13±4．02）mm比（57．62±4．77）mm，（37．76±3．02）mmt：g（41．89±3．53）mm]（t=4．135、4．253，P〈0．05）。阿托伐他汀组治疗后血浆CRP．,BNP水平[（11．86士4．11）mg／L和（247．92±32．78）nrCL]较治疗前[（19．62±7．93）mg／L和（496．61±78．87）ng／L]明显下降（t=4．668、4．821，P〈0．059，并且明显低于同期对照组[（16．79．4-6．52）mg／L和（475．41±65．62）ng，L]（t=3．889、4．011，P〈0．05）。结论阿托伐他汀能够明显改善慢性充血性心力衰竭患者的心功能状态，降低血浆CRP和BNP水平，有利于改善患者病情。
Objective To observe the effect of atorvastatin on heart function of patients with chronic congestive heart failure （CCHF） and the changes of brain natriuretie peptide （BNP）,C-reactive protein （CRP）. Methods Seventy-eight patients with CCHF were divided into control group and atorvastatin group by random number table with 39 cases each. Patients in control group were treated with routine treatment such as diuretic, inotropic agents, beta receptor blockers, and atorvastatin group were treated withatorvastatin calcium 20 mg once a day at the base of routine treatment. After treatment for 6 months, the levels of left ventricular ejection fraction （LVEF）, left ventricular end-diastolic dimension （LVEDd）, left ventricular end-systolic dimension （LVESd） and CRP, BNP were detected and compared between two groups. Results After treatment, the level of LVEF was significantly increased and the levels of LVEDd,LVESd were significantly decreased in two groups （P 〈 0.05 ）. Moreover, the level of LVEF in atorvastatin group was significantly higher than that in Control group [ （46.75 ± 5.82）% vs.（40.58 ± 4.92）%]（t = 4.016, P 〈 0.05）, and the levels of LVEDd, LVESd in atorvastatin group were significantly lower than those in control group [ （49.13±4.02） mm vs.（57.62± 4.77） mm, （37.76± 3.02） mm vs.（41.89 ± 3.53） mm]（t =4.135,4.253, P 〈 0.05 ）. The levels of CRP, BNP after treatment in atorvastatin group [ （ 11.86 ±4.11 ） mg/L and （247.92± 32.78 ） ng/L ] were significantly decreased compared with those before treatment [ （ 19.62 ±7.93） mg/L and （496.61 ±78.87） ng/L] （t =4.668,4.821,P 〈0.05）,and the levels of CRP,BNP were significantly lower than those in control group [（16.79±6.52） mg/L and （475.41±65.62） ng,/L] （t = 3.889,4.011, P 〈 0.05 ）. Conclusion Atorvastatin can significantly improve heart function in patients with CCHF and reduce the plasma levels of CRP and BNP, which is good for CCHF patients to improve conditions.
出处
《中国医师进修杂志》
2012年第7期11-13,共3页
Chinese Journal of Postgraduates of Medicine
关键词
心力衰竭
充血性
利钠肽
脑
C反应蛋白质
阿托伐他汀
心功能
Heart failure,congestive
Natriuretic peptide,brain
C-reactive protein
Atorvastatin
Heart function
