摘要
胃癌是我国最常见的恶性肿瘤之一,发病率和死亡率均较高。胃癌的发生由遗传和环境等诸多因素相互作用所致,是一个多因素、多基因、多步骤参与的癌变过程,涉及大量相关基因的结构和表达异常,其中c-met、Bmi-1、HER-2/neu和基质金属蛋白酶(MMP)-9等的活化在胃癌的发生、发展中起重要作用。本文就近年胃癌相关基因及其在胃癌治疗中的研究进展作一综述,旨在帮助理解胃癌发生、发展的分子机制,并为其基因靶向治疗提供一定的理论依据。
Gastric cancer is one of the most common malignant tumors with high prevalence and mortality. The genesis of gastric cancer is the result of the interaction between genetic and environmental factors, and is a multi-factor, multi-gene, and multi-step process involving structural and expression abnormalities of many related genes, of which the activation of gene c-met, Bmi-1, HER-2/neu and matrix metalloproteinase （MMP）-9 is of great importance. This article reviewed advances in study on gastric cancer related genes and their application in treatment of gastric cancer, for better understanding of molecular mechanisms of the occurrence and development of gastric cancer, so as to provide some theoretical basis for targeted gene therapy of gastric cancer.
出处
《胃肠病学》
2012年第1期53-55,共3页
Chinese Journal of Gastroenterology
关键词
癌基因
胃肿瘤
RNA
小分子干扰
信号传导
Oncogenes
Stomach Neoplasms
RNA, Small Interfering
Signal Transduction
