摘要
目的:观察P53(P53蛋白)、PCNA(增殖细胞核杭原)和P-gp(P-糖蛋白)在人食管癌组织中的表达,探讨其与食管癌临床病理学的关系。方法:采用S-P免疫组化法检浏57例食管癌组织标本及12例正常食管组织标本中P53、PCNA和P-gp的表达。采用χ2检验对结果进行统计学分析。结果:1.P53和PCNA在正常食管组织与食管癌组织中的表达存在非常显著差异(P<0.01)。2.P53和PCNA在不同分化程度的食管癌组织中的表达存在显著差异(P<0.05)。3.P53在有无淋巴结转移的食管癌组织中的表达存在显著差异(P<0.05);而PCNA的表达存在不显著差异(P>0.05)。4.P53和PCNA在不同PTNM分期的食管癌组织中的表达存在不显著差异(P>0.05)。5.P-gp的表达与食管癌的发生及临床病理学特征无关(P>0.05)。结论:P53、PCNA的表达与食管癌的发生及临床病理学特征有关,可作为一个新的评价食管癌的指标;而P-gp的表达与食管癌的发生及临床病理学特征无关。
Objective：Observing the expression of P53.PCNA and P-gp in human esophageal carcinoma,and discussing the relationship between P53.PCNA.P-gp and the clinical-pathological characteristics of esophageal carcinoma.Methods：The S-P immunohistrochemical staining is selected to detect the expression of P53.PCNA and P-gp in 57 esophageal carcinoma samples and 12 normal esophageal tissue samples.The results are analyzed with χ2-test in statistics.Results：1.There is a significant diversity in the expression of P53 and PCNA between normal esophageal tissue and esophageal carcinoma（P0.01）.2.There is a significant diversity in the expression of P53 and PCNA among different histological grades of esophageal carcinoma（P0.05）.3.There is a significant diversity in the expression of P53（P0.05） and a insignificant diversity in the expression of PCNA（P0.05） between the group with lymphatic metastasis and the group without lymphatic metastasis.4.There is a insignificant diversity in the expression of P53 and PCNA among different PTNM stages of esophageal carcinoma（P0.01）.5.the expression of P-gp has not relation with the produce and clinical-pathological characteristics of esophageal carcinoma（P0.05）.Conclusions：The expression of P53 and PCNA had relation with the produce and clinical-pathological characteristics of esophageal carcinoma,and could be a new data to make judgement of esophageal carcinoma.But the expression of P-gp had not relation with the produce and clinical-pathological characteristics of esophageal carcinoma.
出处
《航空航天医学杂志》
2012年第1期35-37,共3页
Journal of Aerospace medicine
