摘要
目的观察苦参碱联合经导管动脉内化疗栓塞术(Transcatherter Arterial Chemoemboliza-tion,TACE)治疗肝癌的临床疗效。方法将67例患者随机分为二组,观察组36例与对照组31例,均采用相同的TACE治疗,观察组同时联合苦参碱注射液治疗。观察比较二组的疗效,KPS评分、体质量和不良反应发生情况。结果观察组与对照组近期疗效分别为44.4%和41.9%,差异无统计学意义(P>0.05);观察组治疗前后KPS评分值上升,经比较差异有统计学意义(P<0.05),且对照组治疗后KPS评分值下降,治疗前后经比较差异无统计学意义(P>0.05);二组患者治疗前后体质量均无明显变化(P>0.05);观察组不良反应(包括白细胞减少、血红蛋白下降、肝功能损害等)发生率比对照组低,且差异有统计学意义(P<0.05)。而在血少板减少和恶心呕吐发生率及肾功能损害等不良反应的发生率方面,二组间差异无统计学意义(P>0.05)。结论苦参碱注射液联合TACE治疗原发性肝癌,可以提高患者的生活质量,并减轻化疗的一些不良反应。
Objective To observe the clinical efficacy of matrine injection combined with transcatheter arterial chemoembolization（TACE） on hepatocellular carcinoma（HCC）.Methods All of 67 patients with HCC were divided into two groups： the observation group（n=36） and the control group（n=31）.Control group received TACE therapy only,and the observation group was given matrine injection combined with TACE.The response rate（RR）,KPS scores,body weight,and adverse reaction were observed.Results The short term efficacies of observation group and control group were 44.4% and 41.9% respectively,the difference was not significant（P0.05）.The KPS score of the observation group was elevated after treatment,and the difference was significant（P0.05）.The KPS score of the control group tended to decrease after treatment,but there was no significant difference（P0.05）.The body weight was not significantly different before and after treatment in the two groups（P0.05）.The occurrence rate of adverse drug reaction such as leucopenia,hemoglobin decrease,and liver function damage were lower in the observation group than that in the control group（P0.05）.The incidence of thrombocytopenia,nausea or vomiting,and renal function damage had no significant difference between the two groups（P0.05）.Conclusion Matrine injection combined with TACE can improve the life quality of patients with hepatocellular carcinoma and decrease adverse reactions induced by chemotherapy.
出处
《中国煤炭工业医学杂志》
2011年第11期1625-1627,共3页
Chinese Journal of Coal Industry Medicine
