摘要
目的:探讨舌鳞状细胞癌(舌鳞癌,TSCC)组织中HIF-1α、MMP-9及PTEN的表达及临床病理意义。方法:应用免疫组化SP法检测20例正常舌黏膜组织及45例舌鳞癌组织中HIF-1α、MMP-9及PTEN蛋白的表达情况。结果:HIF-1α、MMP-9的阳性表达率在病例组(分别为88.89%、68.89%),明显高于正常组(分别为30%、5%)(P<0.01)。PTEN的阳性表达率在病例组(28.89%)低于正常组(80.00%)(P<0.01)。HIF-1α与MMP-9呈正相关(P<0.05),MMP-9与PTEN呈较强负相关(P<0.01),HIF-1α与PTEN呈负相关(P<0.05)。结论:HIF-1α、MMP-9在舌鳞癌的发生、发展过程中可能起着协同作用,PTEN可以拮抗HIF-1α、MMP-9。三者指标均可在舌鳞癌早期作为诊断指标。
Objective： To study the expression of HIF-1α,MMP-9 and PTEN in tongue squamous cell carcinoma and investigate their clinical significance.Methods： SP method was used to detecte 20 cases of normal tongue mucosa and 45 patients with tongue squamous cell carcinoma of HIF-1α,MMP-9 and PTEN expression.Results： HIF-1α and MMP-9 in the positive rate of TSCC（88.89%,68.89%） were significantly higher than the nomal tongue mucosa（30%,5%）（P0.01）.PTEN expression in normal tongue mucosa was 80.00% and tongue squamous cell carcinoma was 28.89%,which had a significant difference between groups（P0.01）.There was positive correlation between the HIF-1α and MMP-9 expression（P0.05）.However,there was inverse correlation between MMP-9 and PTEN expression（P0.01）,also inverse correlation between HIF-1α and PTEN expression（P0.05）.Conclusion： HIF-1α and MMP-9 in tongue squamous cell carcinoma may play an collaborative role in the event of the development process.PTEN may antagonize HIF-1α and MMP-9 expression,which suggested that the detection of HIF-1α and MMP-9 PTEN could be an early diagnosis.
出处
《口腔医学研究》
CAS
CSCD
北大核心
2011年第10期896-898,901,共4页
Journal of Oral Science Research
