摘要
目的探讨CD147和其下游基因MMP2、MMP9在非霍奇金淋巴瘤(NHL)中的表达及临床病理意义。方法应用免疫组化SP法检测石蜡包埋100例NHL和10例淋巴结良性病变组织中CD147,MMP2和MMP9的表达情况,分析两者之间的相互关系及其与NHL生物学行为的相关性。结果NHL中CD147,MMP2的表达均显著高于对照组(P=0.018,0.023),而MMP9的表达差异无统计学意义。CD147与MMP2和MMP9间均存在正相关关系(P=0.016,0.034),但三种抗原表达与NHL患者性别、发病部位、临床分期间均无统计学相关性;仅BCL中CD147,TCL中CD147、MMP2的表达与对照组比较差异有统计学意义(P=0.045,0.015,0.001)。结论NHL高表达CD147并通过诱导MMP2和MMP9,尤以MMP2的明显表达从而影响其生物学行为,这种影响贯穿NHL的整个临床进展过程。
Objective To investigate the expression of CD147, MMP-2, MMP-9 and its clinicopathology in non-Hodgkin's lymphoma. Methods Immunohistochemical S-P method was used to detect the expression of CD147, MMP-2 and MMP-9 in formalin-fixed, paraffin-embedded 100 non-Hodgkin's lymphomas (NHL) and 10 benign lymph node pathological changes. The relationship between CD147 and MMP-2, MMP-9 expression, together with the relationship between these proteins and biological activity of NHL was further investigated. Results The expression of CD147 and MMP-2 were high in NHL group while low in the control group (P= 0.018, 0.023, respectively). As for MMP-9, the case had no signification. There were correlation between expression of CD147 and MMP-2, MMP-9(P= 0.016, 0.034, respectively).And there were no correlation between the expression of three proteins and NHL patient sex, lesions and Ann Arbor stages. Only CD147 expression in B-cell lymphoma and T-cell lymphoma, MMP-2 expression in T-cell lymphoma had signification versus to the control group (P= 0.045, 0.015 and 0.001, respectively). Conclusion Overexpression of CD147 in NHL induces the expression of MMP-2 and MMP-9, especially, the expression of MMP-2, affecting the biological progression of NHL with the whole clinical stages.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2005年第7期420-422,455,共4页
Cancer Research on Prevention and Treatment
基金
广东医学院青年基金资助项目(XQ0303)
