摘要
目的对92例分化型甲状腺癌术后131I治疗的临床效果进行分析。方法 92例分化型甲状腺癌患者术后行131I清甲治疗,剂量为50～150 m Ci,25例未发现转移患者治疗1～2次后定期随访,61例有远处转移患者长期阶段性治疗,每次给予150～200 mC i,每次治疗间隔6个月,少数病例间隔6～12个月,治疗中6例失随访,11例因病灶不摄取131I放弃治疗或病情恶化、死亡。合并转移患者治疗疗效判断:①治愈;②好转或稳定;③无效或恶化。患者随访期1～9年。结果 92例DTC患者清甲治疗后一次清甲完全者75例(87.2%),61例转移患者治疗后治愈者14例(23.0%),好转36例(59.0%),11例治疗无效。治疗期间未见严重毒副作用。结论分化型甲状腺癌患者术后131I治疗能够有效降低复发和转移,对于合并转移患者疗效较为满意,同时应加强宣传,提倡合理规范手术,提高DTC患者术后131I治疗比例。
Objective To investigate the clinical efficacy of 131 I treatment for differentiated thyroid cancer.Methods Ninety two cases of differentiated thyroid cancer received 131 I treatment after thyroidectomy with doses of 50-150 mCi per treatment.25 patients without metastases were treated one or two times and followed up regularly;61 patients with remote metastases received long-term periodic 131 I treatment,with doses of 150-200 mCi per treatment and time intervals of 6 months,several cases with time intervals of 6-12 months.There were 6 patients lost to follow-up.11 patients were excluded from further 131 I therapy due to absence of 131 I up take by the metastases or deterioration,death.Assessment of metastases therapeutic results：①cured;②improved or controlled;③none effective.The follow-up time ranged from 1 to 9 years.Results 92 cases underwent 131 I-ablating therapy for remnant thyroid with 75 patients（87.2%） achieved successful thyroid remnant ablation at first dose.Among all 61 patients with remote metastases after 131 I treatment,16 patients（23.0 %） were completely cured,36 patients（59.0 %） were improved and 11 patients were none effective.All patients had no serious adverse reactions during the treatment.Conclusion 131 I treatment in DCT patients after thyroidectomy may effectively reduce tumor relapse and metastasis and had obtained a more satisfactory curative effect for the patients with metastases.At the same time we should strengthen the propaganda,advocate rational surgery and improve 131 I treatment proportion of the DTC patients after thyroidectomy.
出处
《中华全科医学》
2011年第10期1517-1519,共3页
Chinese Journal of General Practice
