摘要
目的探讨青少年甲状腺功能亢进(甲亢)患者检测早期肾脏功能损害指标的临床意义。方法放射免疫法(RIA)测定50例健康青少年及120例青少年甲亢患者的血、尿β2微球蛋白(β2-m)及尿清蛋白(UAlb)水平,同时检测血清三碘甲腺原氨酸(T3)、甲状腺素(T4)、肌酐(Cr)、尿素氮(Urea)水平,并进行统计学分析。结果初诊组与未缓解组血、尿β2-m、UAlb水平均高于对照组及治愈组(P<0.05),未缓解组高于初诊组(P<0.05)。甲亢患者血清β2-m与T4水平具有良好的相关性(r=0.92,P<0.05)。结论联合检测青少年甲亢患者血、尿β2-m及UAlb水平,对于早期诊断肾脏损伤的部位和程度及判断患者病情程度等具有一定的临床意义。
Objective To study the clinical value of indexes,related with primary damages of kidney,in adolescent patients with hyperthyroidism.Methods The levels of serum β2-microglobulin（β2-m）,3,5,3′-triiodothyronine（T3）,thyroxin（T4）,creatinine（Cr）,urea nitrogen（Urea）,and urine β2-m and albumin（UAlb） of 50 healthy controls（as control group）and 120 adolescent patients with hyperthyroidism were measured and statistically analyzed.Results Levels of serum β2-m,urinary β2-m and UAlb of the patients group with preliminary diagnosed hyperthyroidism and group with unrelieved hyperthyroidism were significantly higher than those of control group and cured group（P〈0.05） and those of patients group with unrelieved hyperthyroidism were significantly higher than those of group with unrelieved hyperthyroidism（P〈0.05）.There was positive correlation between serum β2-m and T3 in patients with hyperthyroidism（r=0.92,P〈0.05）.Conclusion It should be great clinical significance to measure serum and urine β2-m,combined with UAlb,for diagnosing the site and degree of the damages of kidney as well as evaluating the severity of the disease in adolescent patients with hyperthyroidism
出处
《国际检验医学杂志》
CAS
2011年第12期1310-1311,共2页
International Journal of Laboratory Medicine
