摘要
目的探讨结直肠癌患者手术部位感染(SSI)的相关因素。方法回顾性调查2007年1月-2009年12月行结直肠癌择期手术的208例病例,并进行病例对照研究,采用单因素、多因素logistic回归分析的方法筛选与发生SSI相关的危险因素。结果大肠埃希菌是手术部位感染的主要病原菌,其中产超广谱β-内酰胺酶(ESBLs)的占88.24%;多因素分析显示,手术时间>3.5 h(P=0.001;OR=9.231)、术前空腹血糖>6.1 mmol/L(P=0.032;OR=2.555)、高密度脂蛋白<1.03 mmol/L(P=0.023;OR=2.098)是结直肠癌手术部位感染的危险因素,而腔镜手术(P=0.011;OR=0.092)则是保护因素。结论结直肠癌手术部位感染的主要病原菌是产ESBLs的大肠埃希菌,手术时间、术前空腹血糖、高密度脂蛋白和是否腔镜手术是SSI的影响因素。
OBJECTIVE To investigate the factors associated with surgical site infection in colorectal cancer patients. METHODS From Jan 2007 to Dec 2009, clinical data of 208 patients underwent selective colorectal cancer operation were analyzed retrospectively. Risk factors for SSI were screened. RESULTS Escherichia coli was the main pathogenic bacteria from surgical site, the ESBL production rate was 88. 24%. Multivariate logistic regression analysis revealed operative time 〉3.5h （P= 0. 001;OR = 9. 231）, preoperative fasting plasma glucose ~6. lmmol/L （P= 0. 032 =OR = 2. 555）, high-- density lipoprotein （HDL） 〈 1.03mmol/L （P = 0. 023 ; OR = 2. 098） were the risk factors while laparoscopic operative （P= 0. 092;0R= 0. 092） was protective factor for SSI in patients with eolorectal cancer. CONCLUSION The main pathogen for SSI was ESBL-producing E. coli. Operative time, preoperative fasting plasma glucose increasing, lower HDL level, laparoscopic operative are the most important factors associated with SSI in colorectal cancer patients.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第13期2691-2693,共3页
Chinese Journal of Nosocomiology
