摘要
为探讨国产４种青石棉致大鼠胸膜间皮瘤的潜能，右侧胸膜腔注入青石棉４０ｍ ｇ 诱发大鼠胸膜间皮瘤。结果显示： 各组间皮瘤诱发率在５６．０％ ～６８．８％ （盐源组最高），第１例间皮瘤的存活时间在２３７～３７４天（盐源组最短），间皮瘤鼠的平均存活时间分别为５６０天，４９０天，５９３天，４９８天（盐源组最短）。青石棉诱发的间皮瘤组织学类型以纤维型为主。间皮瘤的分化程度以中、低分化为主。结果表明，胸膜腔注入石棉后均可诱发出胸膜间皮瘤。生理盐水组没有间皮瘤发生。该实验各石棉组中盐源青石棉致间皮瘤的潜能较强。
In order to investigate the potential of pleural mesothelioma induced by crocidolite,author collected samples from four county areas ( Dayao,Yaoan, Muding and Yanyuan) in China. A suspension of 1 ml containing 20mg crocidolite fiber was injected into the right pleural cavity of each rat in various test groups and UICC crocidolite group, totally 40 mg. The negative control was given saline. The results showed that the incidence of mesothelioma was 56.0% 68.8% (in which the rate of induction in Yanyuan group was the highest), and the survival time of the first case of mesothelioma was 273 347 days in the test groups, the Yanyuan group had shorter latency, and the mean survival days of the rats with mesothelioma for four groups were 560, 490, 593 and 498 days respectively; the shortest mean survival time was that for Yanyuan group. The major histological type of mesothelioma induced by crocidolite was the fibrous type. The degree of differentiation in all mesotheliomas was mainly intermediate and low. The results suggested that when rats were intrapleurally inoculated with samples of crocidolite and saline, an appreciable proportion of animals developed mesothelioma except those of the saline group. Compared with other groups, the Yanyuan group had stronger potential of crocidolite induced mesothelioma.
出处
《华西医科大学学报》
CAS
CSCD
1999年第3期286-288,共3页
Journal of West China University of Medical Sciences
