摘要
目的研究不同时间乳酸清除率和血乳酸水平对脓毒性休克患者预后的预测价值。方法 2009年1月至2010年4月,90例脓毒性休克患者入住重症监护病房(ICU)后进行动脉血乳酸水平测定,6、12和24h后再次行动脉血乳酸测定,并计算12和24h后的乳酸清除率。入住ICU24h内,行急性生理学及慢性健康状况评分Ⅱ(APACHEⅡ),统计28d死亡率,将患者分为存活组和死亡组,比较存活组和死亡组的动脉血乳酸清除率与乳酸水平的差异。结果存活组12和24h后,乳酸清除率水平高于死亡组,而血乳酸水平低于死亡组(P均<0.05)。所有患者12和24h后,乳酸清除率水平与APACHEⅡ评分呈负相关(相关系数分别为-0.583和-0.347),而血乳酸水平与APACHEⅡ评分呈正相关(相关系数分别为0.556和0.387)。结论 12h乳酸清除率和血乳酸水平可作为评估脓毒性休克预后的指标。
Objective To retrospectively analyze the value of lactate clearance rate and lactate level in the prognosis of patients with septic shock.Methods From January 2009 to April 2010,the data of 90 septic shock patients was collected in ICU,including the score of acute physiology and chronic health evaluationⅡ （APACHEⅡ）,the arterial centigrade of lactate on admission and after 6,12 and 24 h.At the same time,the lactate clearance rates after 12 and 24 h and the survival numbers of patients in 28 d were recorded.All patients were divided into survival group and death group.The differences between them were compared for statistical significance.Results Compared with the death group,lactate clearance rates were significantly higher,while lactate levels were lower in the survival group after 12 and 24 h （P0.05）.The lactate clearance rates at 12th and 24th h were negatively correlated with APACHEⅡ score （r=-0.583,-0.347）.The lactate levels at the same times were positively correlated with APACHE Ⅱ score（r=0.556,0.387）.Conclusion The lactate clearance rate and lactate level at 12th h can be valuable to predict the prognosis of septic shock.
出处
《中华危重症医学杂志（电子版）》
CAS
2010年第4期21-23,共3页
Chinese Journal of Critical Care Medicine:Electronic Edition
