摘要
目的探讨新生儿重症监护病房(NICU)抢救存活早产儿的神经发育情况及影响因素。方法 通过电话或信件通知的方式,对2007年1月至2008年1月本院NICU收治的140例早产儿在其6个月至1岁半时进行神经心理发育测试和体格发育指标测量,并测定发育商(DQ)。根据DQ评分将随访早产儿分为神经发育正常组及神经发育异常组,对两组早产儿的基本情况、出生时临床特征、家庭和产前因素进行对比分析,进行多因素Logistic回归,计算相对危险度。结果 140例早产儿胎龄(34.4±1.8)周,出生体重(2206±564)g。DQ评分无优秀及中上者,中等、中下和智能低下者分别为75例(53.6%)、56例(40.0%)和9例(6.4%)。多因素Logistic回归提示出生体重、家长给孩子的经济投入、父亲文化程度与早产儿神经心理发育存在相关。结论 NICU抢救存活早产儿婴幼儿期神经心理发育落后的比例较高,与出生体重、家长对孩子的重视程度及父亲的文化程度密切相关。
Objective To study the neurodevelopmental outcome of preterm infants who were discharged from neonatal intensive care unit（NICU） and the impact factors contributing to the neurodevelopmental outcome.The purpose of this study is to find the high risk factors on prognosis of preterm infants and take them as the benchmark in early intervention.Methods A total of 140 preterm infants who accepted treatment in our department from Jan.2007 to Jan.2008 were followed up and analyzed retrospectively at six months to a year and a half in the study.Their clinical data and prenatal data were integrated.The infants received the infant development test of 0-6year-old children Intelligence Developmental Scale for neurological development.The neurodevelopmental outcome was evaluated based on Developmental quotient（DQ）.DQ85 was defined as normal,DQ between 70 and 85 as critical and DQ70 as abnormal.Meanwhile their DQ and influencing factors were researched.Social-domestic and clinical factors related to neurological development were analyzed by Independent-samples T Test or Chisquare Test.Potential high risk factors were analyzed with Logistic regression.The data were arranged and analyzed with SPSS 11.5.Results This study consisted of 140 preterm infants,with a mean gestational age of（34.4±1.8） weeks and a mean birth weight of（2206±564） g.Normal,critical and abnormal neurological development occurred in 75 cases（53.6%）,56 cases（40.0%） and 9 cases（6.4%） respectively.Logistic regression showed birth weight,the economic input which parents gave to their children and education level of father were related to DQ scores.Conclusions Preterm infants discharged from NICU are a high risk group of neurodevelopmental disablement.It is closely related to the perinatal high risk factors,which causes nervous system lesions.First of all,health care should be strengthened during pregnancy pregnancy.At the same time proper adequate nutrition and early education are recommended.Secondly,parents should pay attention to neurodevelopmental outcome of preterm infants,establish a good doctor-patient relationship and assess the neurodevelopmental outcome regularlly,for early rehabilitation and improve long-term quality of life of perterm infants at high risk.
出处
《中国新生儿科杂志》
CAS
2011年第2期95-98,共4页
Chinese Journal of Neonatology
关键词
发育商
影响因素
预后
婴儿
早产
Developmental quotient
Multi-variable
Prognosis
Infant
premature
