摘要
由微生物和植物产生的聚酮类化合物(PK)的数量庞大,是一大类结构多样化和生物活性多样性的天然产物,已经成为新药的重要来源。综述了3种类型聚酮类化合物生物合成基因簇的特点,即以模块形式存在的I型聚酮合酶、包含一套可重复使用结构域的Ⅱ型聚酮合酶以及不需要ACP参与,以植物中的查耳酮合酶为代表的Ⅲ型聚酮合酶。介绍了近年来组合生物合成技术的基本原理、聚酮合酶的基本作用机制以及合成途径的研究进展。
The polyketides from microorganisms and plant which are comprise of a large and structurally diverse family of bioactive natural products,are still indispensable for drug discovery.Three types of polyketide synthase were briefly introduced,including the modular（TypeⅠ）PKS,TypeⅡ polyketides,in the synthesis of which a set of discrete monofunctional proteins were repeatedly employed and Type Ⅲ PKSs（chalcone synthase-like protein）that does not require acyl-carrier proteins（ACPs）.The status of combinatorial biosynthesis technology in microbial medicine researches including polyketides and the machineries of three types of polyketide synthase were also mentioned in this paper.
出处
《现代农业科技》
2011年第3期24-26,共3页
Modern Agricultural Science and Technology
关键词
聚酮类化合物
应用
组合生物合成
微生物药物
polyketide
application
combinatorial biosynthesis
microbial medicine
