摘要
目的:制备超顺磁性四氧化三铁壳聚糖纳米粒,并检测物理和磁学性质。方法:共沉淀法制备超顺磁性四氧化三铁壳聚糖纳米粒,通过透射电镜与原子力显微镜、X射线粉末衍射法、振动样品磁场计和激光衍射粒度分析仪初步分析其形态和磁性。结果:所得样品核心为四氧化三铁晶体,粒径为20～30 nm,矫顽力为0.532 oe,剩磁为1.281 8×10-5 emu,饱和磁化0.01152 emu。结论:制备的样品具有粒径小,分散性好,超顺磁性的特点,可以作为非病毒基因的载体。
Objective：To prepare superparamagnetic Fe3O4 chitosan nanoparticle and detect its physicalmagnetic properties.Methods：Superparamagnetic Fe3O4 chitosan nanoparticles were prepared through chemical coprecipitation.The sample was analysed with configuration and magnetism by transmisson electron microscopy and atomic force microscopy,X-ray powder diffraction,vibrating sample magnetometer,laser diffraction particle size analyser,respectively.Results：The core of sample was Fe3O4 crystal,with the diameter of chitosan-coated particles ranging from 20 to 30 nm,the coercive force of 0.532 oe,residual magnetism of 1.281 8×10-5 emu and saturation magnetization of 0.011 52 emu. Conclusion：Small size,good dispersibility and superparamagnetic characteristic make Fe3O4 chitosan nanoparticle as a non-viral gene carrier.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2010年第11期1690-1692,共3页
Journal of Chongqing Medical University
基金
重庆市卫生局重点课题(编号:渝卫科教[2007]1号)
重庆市教委课题(编号:渝教科[2007]5号)
关键词
超顺磁性
壳聚糖
纳米粒
矫顽力
Superparamagnetism
Chitosan
Nanoparticles
Coercive force
