摘要
目的评价吸烟对慢性阻塞性肺病(COPD)全身系统性炎症反应的影响。方法该横断面研究共纳入144名研究对象,分为四组:不吸烟对照组(n=36),吸烟对照组(n=30),不吸烟伴COPD组(n=41),吸烟伴COPD组(n=37)。用酶联免疫吸附法(ELISA)测量每组研究对象的血清C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)以及白细胞介素-6(IL-6)等炎症因子水平。结果吸烟引起研究对象血清CRP、TNF-α、IL-6等炎症因子水平升高(均P<0.05),多元Logistic回归提示TNF-α水平与研究对象吸烟状态及罹患COPD都独立相关(均P<0.05),CRP、IL-6水平仅与研究对象罹患COPD独立相关(均P<0.05)。结论吸烟会引起全身系统性炎症反应增高,这种增高可能是由TNF-α介导的,并且可能在COPD的发病中起着重要的作用,该研究结果提示戒烟可能会降低TNF-α介导的全身系统性炎症反应,从而能使COPD患者受益。
Objective To assess the association between systemic inflammation and smoking status in patients with chronic obstructive pulmonary disease（COPD）. Methods Totally 144 patients were included in this cross-sectional study.The patients were divided into non-smoker controls（n=36）,smoker controls（n=30）,non-smokers with COPD（n=41）,and smokers with COPD（n=37）.We measured serum CRP,TNF-α and IL-6 levels in all the patients using enzyme-linked immunosorbent assay（ELISA） kit. Results Smoking increased serum CRP,TNF-α and IL-6 levels in all the patients（all P〈0.05）.Multiple logistic regression analysis showed that TNF-α levels were associated with smoking status and COPD attack（both P〈0.05）.CRP,IL-6 levels were correlated with COPD attack（both P〈0.05） but not with smoking status. Conclusion Smoking may aggravate TNF-α mediated systemic inflammation,which may play a key pathophysiological role in COPD.Smoking cessation may be clinically useful for patients with COPD by inhibiting TNF-α mediated systemic inflammation.
出处
《实用预防医学》
CAS
2010年第11期2298-2300,共3页
Practical Preventive Medicine
关键词
吸烟
慢性阻塞性肺病
系统性炎症反应
Smoking
Chronic obstructive pulmonary disease
Systemic inflammation
