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多西他赛联合顺铂化疗治疗进展期非小细胞肺癌临床研究 被引量:1

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摘要 目的研究多西他赛与顺铂联合化疗治疗进展期非小细胞肺癌患者的疗效和不良反应。方法共入选64例,采用多西他赛60mg/m^2第1天,顺铂70~75 mm^2第2天,3~4周为一个周期,连用2~4周期。结果 59例可评价疗效,部分缓解20例,有效率33.9%,1年生存率37.5%,中位生存时间9.5月。64例均可评价不良反应,WHOⅢ度白细胞、中性白细胞、贫血发生率分别为57.8%、62.5%和7.8%,Ⅳ度中性粒细胞减少发生率48.4%。WHOⅢ度非血液学毒性乏力、呕吐和腹泻发生率分别为35.9%、14.1%和10.9%,因不良反应终止治疗共5例。结论西他赛与顺铂联合化疗治疗进展期非小细胞肺癌患者有效且不良反应可耐受。
出处 《河北医科大学学报》 CAS 2010年第10期1224-1225,共2页 Journal of Hebei Medical University
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