摘要
方药量效关系是中医科学研究的重要课题。方药量效关系的文献与理论研究包括7个方面的主要内容:经方本原剂量考证、方药剂量发展变化历史研究、证-量-效关系研究、方剂结构与量效关系研究、方药量效关系影响因素研究、随证施量原则研究,以及方药临床用量控制策略与方法研究。经方本原剂量目前虽然不能得出最终结论,但方药剂量发展变化历史的研究有助于认识经方的本原剂量。方药量效关系是一种"证-量-效关系",所以对方药关系的理解,不可忽略证的因素。中医临床处方用药应该在辨证论治的原则下,讲究方药用量控制策略与方法,随证施量。由于经方本原剂量尚难确定,所以也不能确定历史上存在经方剂量大幅缩小的变化。大量的临床事实表明,中医方药具有较低的"剂量阈"和较宽的"治疗窗",这与临床病证的复杂性以及患者的个体差异、对方药的反应性有密切关系。中医临床处方用药应该在辨证论治的原则下,讲究方药用量控制策略与方法,随证施量。
In the scientific research of TCM,dose-effect relationship in TCM formulas is one of the most important projects.The documentary and theoretical researches on medicinal dose-effect relationship in TCM formulas include following seven aspects： textual research on the original dosage of classical formulas,and studies on the development and change history of dosage in formulas,syndrome-dose-effect relationship,formula structure and dose-effect relationship,influencing factors of dose-effect relationship,principles of administrating medicinal based on syndromes,and the strategies and methods of controlling dosage in clinical practice.The research on the development and change history of dosage in formulas is beneficial to understand the original dosage of classical formulas,though it is not finally obtained up to the present.Medicinal dose-effect relationship in TCM formulas is a ＂syndrome-dose-effect relationship＂,therefore the TCM syndromes cannot be neglected when researching on dose-effect relationship.On the premise of syndrome differentiation and treatment,the strategies and methods of controlling dosage should be noticed in order to administrate medicinal based on syndromes in clinical practice.Due to the original dosage of classical formulas is not clear,the historical existence of remarkable decrease of dosage of classical formulas is not clear too.A large number of clinical cases have showed that TCM formulas have lower dose threshold and wider therapeutic window,which is closely related to the complexity of syndromes,individual difference and reactivity to TCM formulas.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2010年第9期601-605,640,共6页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)项目(No.2010CB530604)
关键词
方药剂量
量效关系
文献与理论研究
经方本原剂量
剂量阈
治疗窗
medicinal dosage in formulas
dose-effect relationship
literature and theoretical researches
original dosage of classical formulas
dose threshold
therapeutic window
