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循环肿瘤细胞检测的临床应用 被引量:11

Detection of circulating tumor cells:recent progress in clinical applications
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摘要 循环肿瘤细胞是存在于外周血中的少量恶性细胞,起源于原发肿瘤或转移灶.新技术的发展使分离和鉴定循环肿瘤细胞成为可能.循环肿瘤细胞检测已被认为是一个可靠的预后指标.在治疗过程中随时预测疾病的进展和患者的存活时间.而系列监测结果能够更早地为医生提供更多的信息,从而能够制定更明确的治疗方案.本文综述了循环肿瘤细胞检测在乳腺癌、前列腺癌和结直肠癌中的临床应用,希望帮助读者了解循环肿瘤细胞检测的适应证、临床意义和存在的问题. During the process of cancer metastasis,some cancer cells,termed circulating tumor cells(CTCs),are liberated from primary tumor tissue.New techniques have been developed to isolate and characterize these cells.The early detection of CTCs represents not only a powerful diagnostic tool for cancer but also an important predictive and prognostic marker for evaluation of disease progression and treatment response.In this article,we discuss the clinical utility of CTCs detection in breast,prostate,and colon cancer,and explore the future directions in this field.
出处 《世界华人消化杂志》 CAS 北大核心 2010年第22期2346-2349,共4页 World Chinese Journal of Digestology
基金 国家863基金资助项目 No.2007AA02Z461 国家传染病重大专项基金资助项目 No.2008ZX10002-021 国家自然科学基金资助项目 No.30672002 30772513~~
关键词 循环肿瘤细胞 乳腺癌 前列腺癌 结直肠癌 Circulating tumor cell Breast cancer Prostate cancer Colorectal cancer
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参考文献21

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