摘要
对壳聚糖进行O-季铵化改性,并与羧甲基-β-环糊精在均相条件下进行缩合反应,制得O-季铵化壳聚糖固载环糊精(QCSCD),用FTIR、EA和SEM对产物进行表征。以酮洛芬为模型药物,研究其载药及药物释放行为。结果表明,季铵盐基团的引入提高了QCSCD的载药量,为3.97mg/mg,并且改变了QCSCD的pH响应性能。与壳聚糖固载环糊精相反,QCSCD在模拟胃液中的释放速率很快,而在模拟肠液中具有缓释性能。
O-quarternary ammonium chitosan bearing carboxymethyl-β-cyclodextrin（QCSCD）was synthesized by grafting carboxymethyl-β-cyclodextrin onto O-quarternary ammonium chitosan in the presence of EDC and NHS.The structure of QCSCD was characterized by FTIR,EA and SEM.Using ketoprofen（KP）as a model drug,the release behavior of QCSCD in mimic gastric and intestinal solutions was investigated in comparison with that of chitosan bearing cyclodextrin（CSCD）.Experimental results indicated that QCSCD showed a higher drug-loading capacity with the maximum ketoprofen adsorption of 3.97 mg/mg.Compared with CSCD,QCSCD behaved an opposite pH responsibility and represented more stable release of the entrapped ketoprofen in mimic intestinal solution.These results suggested that QCSCD could be used as a potential biodegradable delivery system for controlled release of hydrophobic drugs with pH-responsive capability.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2010年第9期1705-1709,共5页
Chemical Industry and Engineering Progress
基金
国家自然科学基金(20574024)
福建省重点科技项目(2009H0030)
福建省自然科学基金(E0810019
2009J01029)
复旦大学聚合物分子工程教育部重点实验室开放课题
关键词
壳聚糖
季铵化
环糊精
载药性能
chitosan
O-quarternary ammonium
cyclodextrin
controlled release
