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白细胞介素-17调控类风湿关节炎滑膜细胞整合素分子表达与增殖作用研究 被引量:2

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摘要 整合素(integrin)是由α、β2个亚基构成的异二聚体,在脊椎动物中整合素受体家族包括至少17个α亚基和9个β亚基,共同组成超过25种不同的整合素。在类风湿关节炎(rheumatoid arthritis,RA)患者的滑膜细胞表面,以αv,α9,β1为主。本研究采用RA患者滑膜细胞的体外培养制备纤维母细胞样滑膜细胞(fibroblast—like synoviocyte,FLS),研究白细胞介素(IL)-17与整合素表达与调控FLS增殖的作用。
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2010年第8期569-571,共3页 Chinese Journal of Rheumatology
基金 上海市科委重点项目(08JC1413200)
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