摘要
目的探讨过敏性肺炎(HP)的临床和病理特点,提高对HP的认识和诊断水平。方法介绍2例亚急性、1例慢性HP的临床病理学改变,并进行相关文献复习。结果 HP根据临床过程分为急性、亚急性和慢性期改变,急性HP的主要病理改变是急性炎症细胞浸润和急性肺损伤;亚急性HP的主要病理特征为淋巴细胞性间质性肺炎、淋巴细胞性细支气管炎和形成不良的肉芽肿,影像学示两侧肺弥漫小叶中心性结节影;慢性HP具有部分亚急性HP改变并伴有间质纤维化,影像学显示纤维化性间质性肺炎改变。结论 HP临床和病理学改变复杂,易与其他病变混淆,需结合临床、影像学及组织学改变才能做出正确诊断。
Objective To improve our knowledge about the clinical, radiological and pathological features of hypersensitivity pneumonitis （HP） for correct diagnosis. Methods Two cases of subacute HPs and one chronic HP were studied clinically and pathologically. Results Interstitial inflammatory infiltration, cellular bronehiolitis and poor formed granuloma were observed in both subacute HPs. Bilateral small centrolobular nodules on high resolution CT （HRCT） were found in both of cases with patchy ground opacity in one case. The case of chronic HP had highlight feature of centrolobular interstitial fibrosis with bridging extension. The epithelial granulomas were sparse in this case. There were bilateral diffuse stripes of infiltration along the bronchial vesicular bundle with focal patching accentuation on HRCT of chronic HP. Conclusions Approach to the diagnosis of HP is muhidisciplinary because of diverse clinical, radiological and pathological features.
出处
《诊断病理学杂志》
CSCD
2010年第3期176-178,181,共4页
Chinese Journal of Diagnostic Pathology
关键词
过敏性肺炎
外源性过敏性肺泡炎
间质性肺炎
Hypersensitivity pneumonitis
Extrinsic allergic
Interstitial pneumonia
