摘要
α2-受体激动剂作用于外周和中枢神经系统的交感神经末梢,减少去甲肾上腺素的释放,可产生镇静、抗焦虑、抗交感必奋作用以及一定的镇痛作用.临床应用的α2-受体激动剂,主要是可乐定或右旋美托咪啶（dexmedemtomidine,DEX）,可在术前、术中或术后应用,产生镇静、镇痛等作用,同时维持血流动力学稳定,减少阿片类药物的用量及其副作用.
α2-adrenergic agonists produce sedation, anxiolysis, sympatholysis, and possess some analgesic properties because of the effect that decreasing the release of the norepinephrine in the sympathetic nerves ending of peripheral and central nervous system. The uses of α2 -adrenergic agonists such as cloniding and dexmedetomidine in the peri-operative period produced sedation, analgesia, and maintained the hemodynamic state stable. At the same time, it decreased the opioids consumption and its side effects. The clinical uses of clonidine and dexmedetomidine still needs further study.
出处
《国际麻醉学与复苏杂志》
CAS
2010年第3期266-269,共4页
International Journal of Anesthesiology and Resuscitation
