摘要
以小鼠化学性交感神经末梢损伤、家兔尺神经机械损伤为模型及用新生大鼠背根神经节体外无血清培养法，研究神经生长因子（ＮＧＦ）对周围神经损伤及感觉神经元的保护作用。结果表明，ＮＧＦ剂量依赖地提高小鼠颌下腺去甲肾上腺素残留率，提高损伤后兔Ｃ７，Ｔ１背根神经节的细胞数，显著促进新生大鼠背根神经节突起的生长。结果提示，ＮＧＦ对周围神经损伤有明显的保护作用，并对感觉神经元有很强的神经营养作用。
The protective effects of nerve growth factor (NGF) on peripheral nerve injury and sensory neuron growth were studied in three models: peripheral sympathetic nerve injury induced by intraperitoneal injection of 6hydrodopamine (6OHDA), mechanically injured ulnar nerve and cultured dorsal root ganglion (DRG) of newborn rats in vitro. The results indicate that NGF dosedependently increased norepinepherine content in mouse submandibular gland and cell numbers of C7 (seventh cervical vertebra), T1 (first thoracic vertebra) dorsal root ganglion in rabbits, and also dramatically promoted the growth of neuronal projections in cultured DRG. These results suggest that NGF has significant neuroprotiveaction in peripheral nerve injury and a strong neuronutrition on sensory neuron.
出处
《药学学报》
CAS
CSCD
北大核心
1998年第3期180-183,共4页
Acta Pharmaceutica Sinica
关键词
神经生长因子
周围神经损伤
保护作用
Nerve growth factor
Norepinepherine
Nerve injury
Dorsal root ganglion
