摘要
目的:探讨咖啡因对大鼠6-羟基多巴胺(6-OHDA)诱导的帕金森模型作用的量效关系及其最佳用量。方法:应用6-OHDA制备成年大鼠右侧损毁的帕金森病模型,通过外周注射阿朴吗啡促使大鼠旋转次数作为对其病情进行定量检测的指标。用已知不同剂量的咖啡因每天对大鼠灌胃进行治疗,以大鼠旋转次数为主要指标,判断其对帕金森病治疗效果的变迁情况,以探讨咖啡因治疗帕金森病的最佳剂量。结果:咖啡因(30,40,50mg/kg BW)有明显治疗效果,但咖啡因40,50mg/kg BW组对大鼠有可能产生生存质量影响。结论:30mg/kg BW是咖啡因治疗6-OHDA制备帕金森大鼠模型的有效剂量,咖啡因对帕金森病的疗效随剂量增长,到一定剂量时则不再增长。
Objective：To investigate the best dose of caffeine and the dose-effect relationship of caffeine to PD model rats by 6-OHDA. Methods：Rat model with Parkinson disease was built up by direct injecting 6- OHDA into sub stantia nigra pars compacta（SNc）with stereotactic technique. Apomorphine（0. 25mg/kg）was injected celiac to evocate circle behavior. Changes of caffeine effect to PD models were observed by admistrating different doses of caffeine taking the frequency of circle behavior as main index. Results： There were obvious effect on caffeine（30,40,50mg/kg BW）group, but for the rats in caffeine（40,50mg/kg BW）, there would be some influencing factors for their living. Conclusion：30mL/kg rat weight was the best caffeine dose on PD model rats by 6-OHDA. The effect was positive correlation to the dose of caffeine, wouldn＇t grow when the dose came to a fixed amount.
出处
《河北北方学院学报（医学版）》
2010年第1期36-38,共3页
Journal of Hebei North University:Medical Edition
