摘要
目的分析神经系统药品不良反应发生的特点及规律,为临床合理用药提供参考。方法采用回顾性研究方法,对贵州省2006年1月1日～2008年12月31日收集的1672例神经系统药品不良反应报告进行分析。结果神经系统不良反应报告占全部报告的10.45%;患者男女性别比为1:1.04;19～59岁患者占73.10%;药品不良反应累及中枢及外周神经系统(705例)和交感及副交感神经系统(1206例);交感及副交感神经系统损害的临床表现主要为心悸、呕吐和腹泻,中枢及外周神经系统损害的临床表现主要为头晕、头痛和肢体麻木;涉及药物22类,抗感染药物居首位;静脉给药发生不良反应居首位,为956例(57.18%)。结论应重视药源性神经系统损害,及时发现、诊治和预防药源性神经系统不良反应。
Objective To investigate the situation of adverse drug reacdon（ADR） of nervous system（NS）, offer references for rational application in clinical practice. Methods 1 672 reports collected by Guizhou Center for ADR monitoring from Janury, lst 2006 to December, 31th 2008 were analyzed using retrospective study method. Results The reports ofADR of NS accounted for 10.45% in all reports. The ratio of male to famal was 1 ： 1.04. 19-59 years old account for 73.10%. The NS lesion included sympathetic and parasympathetic system（1 206 cases）, central and periphersl nervous system .The clinical manifestations of the former mainly were palpitation, vomiting and diarrhea, the latte＇s mainly were dizziness, headache and local numbness. These ADR cases were induced by 22 kinds of drugs and most of them caused by cephalosporins. Intravenous injection is the main way for administration. Conclusion We should pay attention to drug-induced damage to the NS, timely detect, diagnose, treatment and prevent ADR of NS.
出处
《中国药物警戒》
2010年第2期119-121,共3页
Chinese Journal of Pharmacovigilance
关键词
神经系统
药品不良反应
报告
分析
nervous system
adverse drug reaction（ADR）
report
analysis
