摘要
缺血缺氧的微环境是肿瘤形成和演进过程中普遍存在的现象。在缺氧条件下,肿瘤细胞改变代谢特点以保证存活并不断生长。缺氧诱导因子-1(HIF-1)作为缺氧状态下细胞内重要的转录激活因子,可直接或间接调节100多个靶基因的转录激活,表达靶蛋白,使得肿瘤细胞能适应缺氧微环境,并且保持不断增殖、浸润和转移的能力。
Hypoxic or ischemic microenvironment is a common phenomena in tumor growth and progression. Under hypoxic condition,tumor cells change its metabolic character to keep survive and growth. Hypoxia - inducible factor - 1 （ HIF - 1 ） as the most important transcription activator under the hypoxic condition , it regulates transcription activation of more than 100 target genes directly or indirectly, which help tumor cells adapt to hypoxic environment, and keep the ability of proliferation, infiltration and metastasis.
出处
《现代肿瘤医学》
CAS
2010年第1期166-168,共3页
Journal of Modern Oncology
基金
国家自然科学基金项目(30560057
30860331)
