摘要
目的:探讨阵发性房颤和房性早搏患者的P波离散度(Pd)、左房内径(LAD)和心钠素(ANP)水平的变化及其相关性。方法:共入选阵发性房颤患者40例(A组),频发房性早搏患者50例(B组),正常对照组50例(C组),分别查窦性心律时的12导联心电图,测量最大P波时限(Pmax)及最小P波时限(Pmin)并计算P波离散度(Pd=Pmax-Pmin),超声心动图测量LAD;并取空腹静脉血用放免法测ANP水平。结果:阵发性房颤及频发房性早搏组的LAD、Pmax、Pd、ANP与对照组相比均明显延长(P<0.01);阵发性房颤组与频发房性早搏组相比也有显著性差异(P<0.05);LAD与Pmax、Pd、ANP均呈正相关(r=0.366,r=0.299,r=0.388,P<0.01),ANP与Pmax、Pd也呈正相关(r=0.330,r=0.215,P<0.01);而Pmax与Pd相关性最好(r=0.706,P<0.01)。结论:LAD、Pmax、Pd、ANP均与房性心律失常密切相关。
Objective：To study the relationship of P wave dispersion（Pd）,left atrial dimension（LAD）and atrial natriuretic peptide（ANP）between patients with paroxysmal atrial fibrillation and those with atrial premature beats.Methods：40 patients with paroxysmal atrial fibrillation（group A）,50 patients with atrial premature beats（group B）and 50 healthy controls（group C）were included.The P wave maximal duration（Pmax）and the minimum duration（Pmin）and P wave dispersion（Pd=Pmax-Pmin）were measured using 12 leads electrocardiogram.Left atrial dimension（LAD）was measured by the echocardiogram and ANP was detected by radioimmunoassay（RIA）in each individule.Results：LAD,Pmax,Pd and ANP were higher significantly in patients with paroxysmal atrial fibrillation and atrial premature beats than those in healthy controls（P 〈 0.01）;The significant difference also existed between patients with paroxysmal atrial fibrillation and those with atrial premature beats（P 〈 0.05）;Pmax,Pd and ANP were all correlated with LAD（r= 0.366,r=0.299,r=0.388,P 〈 0.01）and the best correlation was shown between Pmax and Pd（r=0.706,P 〈 0.01）;Pmax and Pd had correlation with ANP（r=0.330,r=0.215,P 〈 0.01）.Conclusion：LAD,Pmax,Pd and ANP are closely related to atrial arrhythmia.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第12期1713-1715,共3页
Journal of Nanjing Medical University(Natural Sciences)
基金
连云港市卫生局科研项目(07020)
关键词
阵发性房颤
房性早搏
P波离散度
心钠素
paroxysmal atrial fibrillation
atrial premature beats
P wave dispersion
atrial natriuretic peptide
