摘要
目的利用甘蔗镰孢Fusarium sacchari对三七茎叶皂苷进行生物转化,以发现新的稀有抗肿瘤活性成分。方法转化产物通过硅胶、凝胶及液相色谱进行分离,得到化合物结构经波谱鉴定。结果分离得到了1个单体化合物,命名为三七皂苷-LZ(notoginsenoside-LZ),鉴定其化学结构为20(S)-3β-hydroxy-12β,23-epoxy-dammar-24-ene-20-O-β-D-xylopyranosyl(1→6)-β-D-glucopyranoside。结论三七皂苷-LZ(notoginsenoside-LZ)为一新化合物。
Objective To study the chemical constituents of transformed products by Fusarium sacchari and to find the rare ginsenosides with anti-tumor effects from the leaves of Panax notoginseng. Methods The compound isolated was separated by repeated silica gel, Sephadex LH-20, and HPI.C chro matography. The structure was identified by analysis of its spectral data. Results A dammarane-type triterpene, notoginsenoside-LZ, 20 （S） 313 hydroxy-1213, 23-epoxy-dammar-24-ene-20-O-13-D-xylopyranosyl （1→6）-13-D-glucopyranoside, was isolated from the transformed products. Conclusion Notoginsenoside-LZ is a new compound.
出处
《中草药》
CAS
CSCD
北大核心
2009年第12期1863-1865,共3页
Chinese Traditional and Herbal Drugs
基金
辽宁省自然科学基金资助项目(20062069)
关键词
甘蔗镰孢
生物转化
三七茎叶皂苷
Fusarium sacchari
biotransformation
saponin in Panax notoginseng （Burk.） F. H. Chen leaves
