摘要
目的检测慢性乙型肝炎（以下简称慢乙肝）患者血浆基质金属蛋白酶-1（MMP-1）、转化生长因子-β1（TGF-β1）水平，探讨其与慢乙肝疾病进展的关系及其在肝纤维化形成的意义。方法检测四组人群共165例（健康组、慢乙肝组、慢乙肝重型组及慢乙肝后肝硬化组）血浆MMP-1、TGF-β1水平，慢乙肝患者行肝脏病理检查。结果慢乙肝、肝硬化、慢乙肝重型患者血浆MMP-1、TGF-β1水平较健康人明显升高（P均〈0．05），且上述3种疾病MMP-1、TGF-β1依次升高，差异有显著性（P均〈0．05）。慢乙肝患者随着炎症升级和纤维化程度的加重，血浆MMP-1水平呈下降趋势，血浆TGF-β1逐渐升高。结论血浆MMP-1与TGF-β1检测可作为反映肝功能的指标，MMP-1、TGF-β1对于慢乙肝炎症和肝纤维化程度的评估有一定的临床应用价值，血浆TGF—β1能更好地反映肝脏炎症和纤维化程度。
Objective The relationships between MMP-1 and TGF-β1 levels and the histological staging of inflammation and fibrosis were explored in patients with chronic hepatitis. Methods Plasma MMP-1 and TGF-β1 levels were detected using ELISA in patients with chronic hepatitis B, chronic severe hepatitis B and post-hepatitis-B cirrhosis, the detection in healthy subjects served as the control. The correlation between the liver histology and plasma MMP1 and TGF-β1 levels were analyzed. Results Both Plasma MMP-1 and TGF-β1 levels in chronic hepatitis, hepatic cirrhosis and chronic severe hepatitis were all significantly higher than those in the control group. MMP-1 and TGF-β1 levels increased gradually in chronic hepatitis, hepatic cirrhosis and chronic severe hepatitis. The differences among these three groups were statistically significant （P〈0.05）. With the degree of inflammation and the stage of fibrosis increasing in chronic hepatitis ascending, plasma MMP-1 levels descended gradually. With the degree of inflammation and stage of fibrosis getting severer, plasma TGF-β1 levels ascended gradually. Conclusions Plasma MMP-1 and TGF-β1 levels could be indices reflecting abnormal liver function. Both plasma MMP-1 and TGF-β1 levels could be clinically valuable for evaluating the degree of inflammation and stage of fibrosis in patients with chronic hepatitis B, with plasma TGF-β1 being more valuable.
出处
《世界感染杂志》
2009年第5期301-303,共3页
World Journal of Infection
基金
广州市医药卫生科技项目（2008-YB-079）
