摘要
应用膦亚胺3与芳基异氰酸酯的氮杂Wittig反应,生成碳二亚胺4,4再分别与酚、醇作用,在碳酸钾或醇钠催化下关环,以72%～88%的产率合成了2-烷(芳)氧基取代-苯并呋喃并[3,2-d]嘧啶-4(3H)-酮衍生物5和6,其结构经IR,1HNMR,MS和元素分析证实.初步生物活性测试表明该类化合物表现出温和的杀菌活性.如5f在50mg/L浓度时,对黄瓜灰霉菌的抑制率为55%.
The aza-Wittig reaction of iminophosphorane 3 with aromatic isocyanates gave carbodiimides 4, which were allowed to react further with various phenols and alcohols in the presence of a catalytic amount of solid potassium carbonate or sodium ethoxide to give 2-alkoxy（aryloxy）-benzofuro[3,2-d]pyrimidin- 4（3H）-ones in 72%-88% yields. Their structures were confirmed by ^1H NMR, MS, IR and elemental analysis. The preliminary bioassays indicated that these compounds possessed moderate fungicidal activities against six kinds of fungi at a concentration of 50 mg/L.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2009年第11期1853-1857,共5页
Chinese Journal of Organic Chemistry
基金
湖北省教育厅重点(No.D200724001)
郧阳医学院优秀中青年科技创新团队计划(No.2008CXG01)资助项目
