摘要
目的了解2005—2008年住院精神疾病患者抗抑郁药物处方习惯及其演变。方法采用一日法对2005—2008年中每年6月1日当天所有住院精神疾病患者抗抑郁药物处方情况进行调查分析,并进一步从抗抑郁药物处方中最常见的疾病、最常使用的抗抑郁药物、平均处方剂量、联合用药和合并用药等方面作分析比较。结果①最常使用抗抑郁药物的精神疾病依次是心境障碍、精神分裂症和神经症;②三环类抗抑郁药物的处方频率逐年下降,选择性5-羟色胺再摄取抑制剂(SSR Is)的处方频率呈现出小范围波动,以文拉法辛、米氮平、曲唑酮为代表的新一代其他递质机制的抗抑郁药处方逐年增加;③单用一种抗抑郁药的处方方式最为常见,合并两种以上抗抑郁药的处方始终占少数;④抗抑郁药物合并抗精神病药物、情绪稳定剂、镇静催眠药,都显示出合并一种的情况占绝大多数,而合并两种其他精神药物的情况只占少数。结论本中心2005—2008年在住院精神疾病患者抗抑郁药物处方习惯和方式方面是比较合理和安全的。新型抗抑郁药物已经在临床得到广泛使用,尤其是SSR Is已成为临床一线抗抑郁用药。
Objective To investigate the changes in the prescriptions of antidepressants for inpatients with psychosis from 2005 to 2008. Methods The prescriptions of antidepressants for all the inpatients with psychosis in Shanghai Mental Health Center were investigated by one day survey on each June 1st from 2005 to 2008.The most common diseases treated with antidepressants,the most commonly used antidepressants,the average dosage of antidepressants and the combination use of antidepressants were analysed. Results The most common diseases treated with antidepressants were affective disorder,schizophrenia and neurosis.The prescription rate of tricyclic antidepressants declined year by year,and that of selective serotonin reuptake inhibitors（SSRIs） fluctuated moderately,while that of antidepressants of newer generation with the other transmitter mechanisms such as venlafaxine,mitrazapine and trazodone increased gradually.Single antidepressant prescription was common,while the combination use of antidepressants accounted for a small portion.Combination use of antidepressants with one psychotropics（antipsychotics,mood stabilizer,sedative hypnotics） was common,while with two were less frequently occurred. Conclusion Prescriptions of antidepressants for patients with psychosis hospitalized in Shanghai Mental Health Center from 2005 to 2008 are relatively safe and reasonable.Antidepressants of newer generation have been widely used in clinics,and SSRIs have been serving as the major antidepressants.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2009年第10期1205-1209,共5页
Journal of Shanghai Jiao tong University:Medical Science
基金
“十五”国家攻关计划(2004BA720A21-02)
国家高技术研究发展计划(“863”计划)(2006AA02Z430)
上海市“登山行动计划”(064119533)
上海交通大学医学院自然科学基金(09XJ21024)~~
关键词
抗抑郁药
处方
住院患者
精神病
时点调查
antidepressants prescriptions inpatients psychosis time point survey
